Table 1

Clinical parameters of the patients with chemosensitive and chemoresistant GCT

SensitiveResistant
Nos. of cases1222
Median age in years (range)28 (20–47)29 (17–56)
Histologya
 Seminoma11
 Nonseminoma1121
Stage at diagnosis (UICCb)
 I03
 II07
 III1212
Initial treatment after surgery
 Surveillance02
 Chemotherapy1220
Follow-up (months)
 Median (range)51 (14–69)39 (11–180)
Relapse free survival (months)
 Median (range)NR7.1 (0–150)
Response to initial treatment
 Complete remission85
 Partial remission, marker −48
 Partial remission, marker +03
 Progressive disease03
 Unknown03
No. of salvage regiments
 Median (range)03 (1–9)
  • a For the POU5F1 immunostaining all seminoma, embryonal carcinoma, and CIS components of both the sensitive and resistant tumors (3 and 2; 6 and 8; and 4 and 6, respectively) are positive, whereas all differentiated nonseminoma components are negative.

  • b UICC, International Union Against Cancer; NR, not reached.