Table 2

Results of tissue array immunohistochemistry of 3439 individual tumors of >100 different types for POU5F1

The organ (in alphabetic order), tumor type, number of cases studied, and positive findings are indicated

OrganTumorSubgroupnPositive
Adrenal glandCarcinomaAdeno-190
AnusCarcinomaSquamous30
BrainGliobl. multif./astrocytoma/46/350
oligodendroglioma/meningioma/24/460
PNET/ependymoma/17/90
gangioneuroma/70
medulloblastoma/estioneuroblastoma/4/20
opticus glioma/cranioph.a1/80
Carotid bodyGlomus tumor110
CervixCarcinomaSquamous/CIS/adeno37/7/40
ColonAdenomaTubular and villous1340
CarcinomaAdeno-470
EndometriumCarcinomaAdeno-610
SarcomaEndometrial stromal sarcoma30
EsophagusCarcinomaSquamous/adeno21/1160
Gall bladderCarcinomaAdeno-230
Glomus tumor110
KidneyCarcinomaClear cell/papillary50/451/0
Chromophobic130
Oncocytoma70
LarynxCarciniomaSquamous460
LiverCarcinomaHepatocellular410
LungCarcinomaAdeno-/squamous/48/500/1
large cell/small cell47/411/0
Lymph nodesLymphomaHodgkin’s500
Non-Hodgkin’s high/low grade690
MALT420
BreastCarcinomaLobular/ductal42/460
Med./muc./tub.27/23/260
Cribriform/apocrine5/30
Phylloidees tumor130
MouthCarcinomaSquamous570
OvaryCarcinomaEndometroid/serous mucinous49/48/200
Brenner/mixed Müllerian tumor9/60
Granulosa cell70
Dysgerminoma22
Gonadoblastoma11
PancreasCarcinomaAdeno-470
ParagangliaParaganglioma100
ParathyroidCarcinomaAdeno-200
Parotid glandCarcinomaMixed150
Acinic cell/mucoepithelial5/60
Phaeochrom.260
PenisCarcinomaSquamous430
ProstateCarcinomaAdeno-, horm. (non-)refract.2000
PIN/BPH24/180
(Small) salivary glandPleom. adenoma490
Lymphoep. lesion50
CarcinomaAdenoid cystic430
Acinic cell360
Adenolymph.300
SkinCarcinomaSquamous/basal81/370
Melanoma440
Merkel cell tumor60
BenignHemangioblastoma80
Nevus380
Appendix tumors250
(Small) intestineCarcinomaAdeno-170
GIST140
StomachCarcinomaIntestinal/diffuse44/230
Soft tissueBenignLipoma/fibrous histiocytoma/Schwann/15/58/350
neurofibroma/leiomyoblastoma/31/70
giant cell tumors of tendon sheet/29/0
hemangioma170
IntermediateHaemangiopericytoma80
Dermatofibrosarcoma protuberans20
MalignantKaposi/liposarcoma25/260
Angiomyolipo./malign. Schwann.1/80
Rhabdomyosarcoma/synovial sarcoma13/30
Angios./fibros./alv. soft part sarc.4/6/10
Epithelioid sarcoma20
TestisSeminoma/nonseminoma49/4749/33b
Adenomatoid tumor100
ThyroidCarcinomaFoll./papill./med.42/48/360
ThymusThymoma230
Urinary bladderCarcinomaTCC1010
Small cell/squamous/adeno-3/5/40
Sarcoma70
UterusMyoma1070
VaginaCarcinomaSquamous50
VulvaCarcinomaSquamous370
VariousCarcinoid480
Adenomatoid tumor100
Mesothelioma230
Controlsc300
  • a Gliob. multif., glioblastoma multiforme; PNET, primitive neuro-ectodermal tumor; cranioph, craniopharyngioma; CIS, carcinoma in situ; MALT, mucosa associated lymphoid tissue; med, medullar; muc, mucinous; tub, tubular; horm (non-)refract, hormonal (non)refractory; angiomyolipo., angiomyoliposarcoma; malign. Schwann., malignant Schwannoma; anglo., angiosarcoma; fibros., fibrosarcoma; alv. soft part sarc., alveolar soft part sarcoma; foll., follical.

  • b If containing seminoma in case of combined tumors or embryonal carcinoma elements.

  • c Included in all seven slides: skin (n = 4); lymph node (n = 2); heart (n = 2); skeletal muscle (n = 2); smooth muscle (n = 2); myometrium (n = 2); thyroid gland (n = 2); liver (n = 2); kidney cortex (n = 2); prostate (n = 2); testis (n = 2); submand. gland (n = 2); proliferative endometrium (n = 2); gray matter cerebrum (n = 2).