Table 1

IC50 drug concentrations of mismatch repair-proficient (293T Lα+) and mismatch repair-deficient (293T Lα) cells

The value marked with an asterisk is taken from Ref. 14 . The values represent the mean ± SD of three independent experiments done in triplicate.

Drug293T Lα+293T Lα
IC50 [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay]
 Chloroethylcyclohexyl nitrosourea (μm)0.92 ± 0.150.87 ± 0.13
 Melphalan (nm)468.5 ± 4.9488 ± 2.8
 Mitomycin C (ng/ml)38.5 ± 8.346.6 ± 12.3
 Psoralen-UVA (J/m2)63.862
 Cisplatin (μm)3.3 ± 0.16.7 ± 1.4
 Etoposide (μm)1.17 ± 0.161.28 ± 0.15
 Camptothecin (nm)114.4 ± 25.1115.1 ± 12.3
N-Methyl-N′-nitro-N-nitrosoguanidine (μm)∗0.05 ± 0.0036.26 ± 0.5
IC50 (clonogenic assay)
 Chloroethylcyclohexyl nitrosourea (μm)0.8190.703
 Melphalan (nm)576678