a

The expanses of genetic lesions that occur within the background of a p16 lesion

These expanses were filtered out of the data as potential hitchhikers on p16 lesions (Table A). Amongst these, p53 mutations go to fixation in more patients than any other lesion (highlighted in grey), potentially indicating a later selective sweep that occurs after the sweeps driven by p16 lesions. Microsatellite loci linked to p16 on the p arm of chromosome 9 have been excluded from this analysis because they are likely to occur as part of the same event that generates LOH in p16.

A. Chromosome 9
MarkerExpanseUnfiltered→p53mut
D9S21690–0.100
5.19 Mb0.1–0.20 (2)0
0.2–0.30 (3)0 (2)
0.3–0.400
0.4–0.500
0.5–0.600
0.6–0.700
0.7–0.800
0.8–0.90 (2)0 (2)
0.9–1.00 (1)0 (1)
D9S9350–0.10 (1)0 (1)
5.19 Mb0.1–0.20 (3)0 (2)
0.2–0.30 (2)0 (1)
0.3–0.400
0.4–0.50 (2)0 (1)
0.5–0.600
0.6–0.70 (1)0 (1)
0.7–0.800
0.8–0.90 (3)0 (3)
0.9–1.000
D9S9250–0.100
18.28 Mb0.1–0.20 (4)0 (3)
0.2–0.30 (1)0 (1)
0.3–0.400
0.4–0.50 (2)0 (2)
0.5–0.60 (1)0
0.6–0.700
0.7–0.800
0.8–0.900
0.9–1.00 (1)0 (1)
p16mut0–0.122
22.2 Mb0.1–0.210
0.2–0.3107
0.3–0.443
0.4–0.522
0.5–0.611
0.6–0.733
0.7–0.800
0.8–0.931
0.9–1.086
p16meth0–0.100
22.3 Mb0.1–0.231
0.2–0.332
0.3–0.431
0.4–0.532
0.5–0.653
0.6–0.721
0.7–0.811
0.8–0.911
0.9–1.052
D9S9320–0.10 (1)0
24.42 Mb0.1–0.20 (1)0
0.2–0.30 (1)0 (1)
0.3–0.40 (1)0
0.4–0.50 (2)0 (1)
0.5–0.600
0.6–0.700
0.7–0.800
0.8–0.900
0.9–1.00 (1)0 (1)
D9S11210–0.100
25.39 Mb0.1–0.20 (1)0
0.2–0.300
0.3–0.40 (1)0 (1)
0.4–0.500
0.5–0.600
0.6–0.70 (1)0
0.7–0.800
0.8–0.90 (1)0 (1)
0.9–1.000
D9S11180–0.10 (1)0
31.92 Mb0.1–0.20 (2)0 (2)
0.2–0.300
A. Chromosome 9
MarkerExpanseUnfiltered→p53mut
0.3–0.40 (1)0 (1)
0.4–0.50 (2)0 (2)
0.5–0.60 (1)0 (1)
0.6–0.700
0.7–0.80 (1)0 (1)
0.8–0.900
0.9–1.00 (1)0 (1)
D9S3010–0.12 (1)0 (1)
67.37 Mb0.1–0.20 (1)0 (1)
0.2–0.33 (2)1
0.3–0.40 (5)0 (4)
0.4–0.530
0.5–0.621
0.6–0.711
0.7–0.80 (1)0 (1)
0.8–0.921
0.9–1.02 (3)2 (2)
D9S9300–0.13 (2)0 (1)
108.69 Mb0.1–0.21 (2)1 (2)
0.2–0.33 (1)2 (1)
0.3–0.43 (2)1 (2)
0.4–0.52 (7)1 (6)
0.5–0.60 (1)0
0.6–0.700
0.7–0.800
0.8–0.900
0.9–1.05 (3)4 (3)
Aneuploid0–0.1186
0.1–0.2113
0.2–0.372
0.3–0.420
0.4–0.571
0.5–0.631
0.6–0.710
0.7–0.810
0.8–0.921
0.9–1.010
B. Chromosome 17
MarkerExpanseUnfiltered→p53mut
D17S12980–0.11 (1)0
3.62 Mb0.1–0.20 (1)0
0.2–0.34 (1)3 (1)
0.3–0.400
0.4–0.510
0.5–0.610
0.6–0.721
0.7–0.800
0.8–0.920
0.9–1.08 (2)1 (1)
D17S15370–0.110
5.85 Mb0.1–0.21 (1)1
0.2–0.31 (4)1 (2)
0.3–0.41 (3)0 (2)
0.4–0.52 (1)1 (1)
0.5–0.61 (1)0
0.6–0.720
0.7–0.81 (1)0 (1)
0.8–0.920
0.9–1.03 (2)1 (2)
TP530–0.13 (2)0
7.51 Mb0.1–0.22 (1)1
0.2–0.32 (1)0
0.3–0.46 (1)2
0.4–0.521
0.5–0.60 (2)0 (1)
0.6–0.720
0.7–0.80 (1)0 (1)
0.8–0.921
0.9–1.083
TP53Di0–0.100
7.51 Mb0.1–0.200
0.2–0.31 (1)0
0.3–0.411
0.4–0.511
0.5–0.600
0.6–0.700
0.7–0.800
0.8–0.900
0.9–1.020
A. Chromosome 9
MarkerExpanseUnfiltered→p53mut
p53mut0–0.122
8.8 Mb0.1–0.266
0.2–0.322
0.3–0.499
0.4–0.533
0.5–0.600
0.6–0.733
0.7–0.811
0.8–0.922
0.9–1.099
D17S7860–0.100
8.75 Mb0.1–0.200
0.2–0.300
0.3–0.400
0.4–0.510
0.5–0.610
0.6–0.700
0.7–0.800
0.8–0.90 (1)0 (1)
0.9–1.03 (2)1 (2)
D17S9740–0.120
10.46 Mb0.1–0.23 (2)0 (1)
0.2–0.33 (5)1 (2)
0.3–0.41 (1)0 (1)
0.4–0.55 (6)2 (5)
0.5–0.610
0.6–0.720
0.7–0.832
0.8–0.921
0.9–1.06 (2)2 (2)
D17S13030–0.100
10.8 Mb0.1–0.22 (2)0 (2)
0.2–0.33 (1)1 (1)
0.3–0.42 (3)0 (1)
0.4–0.56 (1)2
0.5–0.61 (1)0 (1)
0.6–0.71 (3)0 (3)
0.7–0.820
0.8–0.90 (1)0
0.9–1.081
D17S12940–0.12 (3)0 (1)
28.23 Mb0.1–0.21 (6)1 (3)
0.2–0.30 (3)0 (1)
0.3–0.442
0.4–0.51 (2)0 (1)
0.5–0.600
0.6–0.700
0.7–0.800
0.8–0.900
0.9–1.021
D17S12930–0.151
32.41 Mb0.1–0.22 (5)2 (2)
0.2–0.31 (3)0 (2)
0.3–0.42 (2)0 (2)
0.4–0.52 (4)1 (3)
0.5–0.600
0.6–0.70 (1)0 (1)
0.7–0.822
0.8–0.91 (1)1 (1)
0.9–1.02 (2)0
D17S12900–0.13 (3)1 (1)
56.67 Mb0.1–0.22 (1)0 (1)
0.2–0.33 (1)1 (1)
0.3–0.41 (1)0 (1)
0.4–0.50 (1)0
0.5–0.61 (1)0 (1)
0.6–0.700
0.7–0.800
0.8–0.900
0.9–1.01 (1)0 (1)
D17S13010–0.10 (1)0
73.14 Mb0.1–0.20 (3)0 (1)
0.2–0.30 (5)0 (3)
0.3–0.41 (1)0 (1)
0.4–0.50 (3)0 (2)
0.5–0.600
0.6–0.71 (3)1 (3)
0.7–0.810
0.8–0.911
0.9–1.01 (2)1 (2)