Table 2

Tumor formation in p53fp/fp; Cre mice

Cre transgeneMMTVCrea (Nulliparous)MMTVCrea (Multiparous)MMTVCreb (Nulliparous)MMTVCreb (Multiparous)WAPCrec (Parous)
Total number of mice1437192012
 Mammary tumor14 (100%)37 (100%)9 (47%)12 (60%)11 (92%)
 Lymphoma2 (14%)6 (16%)15 (79%)15 (75%)5 (42%)
 Other tumor typesac2 (17%)
Metastasisb7 (50%)13 (35%)1 of 3 (33%), ICd1 of 4 (25%), IC4 (36%)
Multiple mammary tumors11 (79%)22 (59%)3 of 4 (75%), IC7 of 10 (70%), IC8 (67%)
Median tumor latency (months)17.515.510.5119.5
  • a Other tumor types, such as soft tissue tumors.

  • b The number of mammary tumor bearing-mice had metastasis of mammary tumor origin.

  • c –, not detected.

  • d IC, incomplete.