Table 1

Relative gene expression levels in colon polyps of APCmin mice (mean ± SE)

Gene expression levels were determined as described in the “Materials and Methods.” In nos. 1∼5, n = 13 in the wild-type littermate group, and n = 14 in the individual polyp group; in nos. 6∼15, n = 6 in the wild-type littermate group, and n = 10 in the individual polyp group. Significance was determined by t test.

No.GeneWild-type littermateIndividual polypP
1OPNa1.62 ± 0.60430 ± 125<0.01
2MIP-21.74 ± 1.60203 ± 43<0.001
3Gro-α1.40 ± 0.32122 ± 19<0.001
4CXCR21.41 ± 0.35105 ± 23<0.001
5COX-21.41 ± 0.2582 ± 16<0.001
6Cyclin D11.34 ± 0.3419 ± 3<0.001
7SDF-11.23 ± 0.3411 ± 2<0.01
8c-myc1.09 ± 0.186.49 ± 0.96<0.001
9MCSF-11.05 ± 0.154.26 ± 1.60NS
10CD44V61.17 ± 0.283.78 ± 0.61<0.01
11COX-11.07 ± 0.153.24 ± 0.60<0.01
12PPAR-γ1.13 ± 0.220.86 ± 0.24NS
13p21cip/waf11.11 ± 0.170.51 ± 0.07<0.05
14PPAR-δ1.16 ± 0.270.44 ± 0.05<0.05
15PPAR-α1.04 ± 0.120.17 ± 0.03<0.001
  • a OPN, osteopontin; MIP-2, macrophage inflammatory protein-2; Gro-α, growth-related oncogene-α; CXCR2, CXC cytokine receptor 2; COX-1 and −2, cyclooxygenase-1 and −2; SDF-1, stroma-derived factor-1; MCSF-1, macrophage-colony-stimulating factor; NS, not significant; PPAR-α, -δ, and -γ, proliferating peroxisome-activating receptor-α, -δ, and -γ.