Table 2

Inhibition of kinases by HKI-272

KinaseIC50(nm)a
Akt>20,000
Cyclin D1/CDK4>50,000
Cyclin E/CDK2>18,000
CyclinB1/CDK1>18,000
IKK-2>9,000
KDR800
c-Met>35,000
MK2>45,000
PDK1>5000
c-Raf/MEK1>18,000
src1,400
Tpl-2>18,000
  • a The concentration of HKI-272 that inhibits activity by 50% is shown.