Table 2

Stimulation of estrogen-mediated tumorigenesis by SNCG^a,^b

Group	E₂	Tumor incidence (%)							Tumor volume (mm³)
		Week 1	Week 2	Week 3	Week 4	Week 5	Week 6	Week 7	Week 7
MCF-neo1	-	0	0	0	0	0	0	0
MCF-neo1	+	0	0	0	0	20	30	30	44 ± 10
MCF-SNCG6	-	0	0	0	0	0	0	0
MCF-SNCG6	+	40	80	90	90	90	90	90	194 ± 35

^a Ovariectomized mice were treated with or without E₂ pellet. There were total 10 injections for 5 mice in each group, and each injection had 1.5 × 10⁶ cells. Only measurable tumors were used to calculate the mean tumor volume. Statistical comparisons for SNCG-positive clones relative to SNCG-negative clones indicated P < 0.001 for both tumor incidence and mean tumor sizes in the presence of E₂.
^b SNCG, γ synuclein; E₂, estradiol.