Table 2

Summary of differentially expressed genes between the 5-Aza-dCa treated and untreated NB cell line

Affymetrix probe set IDGene symbolFold changebChromosomeDescription
Apoptosis
 215719_x_atTNFRSF64.0310q24.1Tumor necrosis factor receptor superfamily
 202284_s_atCDKN1A3.916p21.2Cyclin-dependent kinase inhibitor 1A
 211078_s_atSTK33.738q22.2Serine/threonine kinase 3
Cell adhesion
 201109_s_atTHBS118.6815q15Thrombospondin 1
 207315_atCD22615.2618q22.3CD226 antigen
 219738_s_atPCDH93.3613q14.3-q21.1Protocadherin 9
 207717_s_atPKP2−5.1812p11Plakophilin 2
Transcription regulation
 206830_atSLC4A106.542q23-q24Solute carrier family 4,
 203081_atCTNNBIP14.531p36.22Catenin, β interacting protein 1
 214009_atMSL3L13.62Xp22.3Male-specific lethal 3-like 1 (Drosophila)
 204349_atCRSP93.445q33.3Cofactor required for Sp1 transcriptional activation
 205092_x_atZBTB13.2814q23.3Zinc finger and BTB domain containing 1
 206644_atNR0B1−3.02Xp21.3-p21.2Nuclear receptor subfamily 0, group B, member 1
 206543_atSMARCA2−3.429p22.3Actin-dependent regulator of chromatin
 206035_atREL−4.652p13-p12V-rel reticuloendotheliosis viral oncogene homolog
 220844_atTCEB3L−5.4618q21.1Transcription elongation factor (SIII) elongin A2
 205688_atTFAP4−7.6316p13Transcription factor AP-4
Signal transduction
 214586_atGPR376.977q31G protein-coupled receptor 37
 206584_atLY964.028q13.3Lymphocyte antigen 96
 205280_atGLRB3.354q31.3Glycine receptor, β
 207859_s_atCHRNB3−3.328p11.2Cholinergic receptor, nicotinic, βpolypeptide 3
 219898_atGPR85−3.567q31G protein-coupled receptor 85
 215669_atHLA-DRB3−7.846p21.3MHC, class II
 209920_atBMPR2−14.122q33-q34Bone morphogenetic protein receptor, type II
Heat shock response
 207714_s_atSERPINH182.7811Heat shock protein 47
 200799_atHSPA1A10.946p21.3Heat shock 70kDa protein 1A
Transport
 220791_x_atSCN11A43p24-p21Sodium channel, voltage-gated, type XI, α
 212907_atSLC30A13.371q32-q41Solute carrier family 30, member 1
 207928_s_atGLRA3−3.414q33-q34Glycine receptor, α3
 214337_atCOPA−3.471q23-q25Coatomer protein complex, subunit α
Immune response
 206513_atAIM27.431q22Absent in melanoma 2
 200904_atHLA-E4.116p21.3MHC, class I, E
 202490_atIKBKAP3.329q34Inhibitor of κ light polypeptide gene enhancer
 215669_atHLA-DRB3−7.846p21.3MHC, class II
Organogenesis
 210579_s_atTRIM1012.86p21.3Tripartite motif-containing 10
 210427_x_atANXA27.3115q21-q22Annexin A2
Metabolism
 219532_atELOVL45.836q14Elongation of very long chain fatty acids-like 4
 207813_s_atFDXR3.1217q24-q25Ferredoxin reductase
 207252_atUBE1−3Xp11.23Ubiquitin-activating enzyme E1
 202015_x_atMETAP2−13.0112q23.1Methionyl aminopeptidase 2
Miscellaneous genes
 219454_atEGFL64.12Xp22EGF-like-domain, multiple 6
 213397_x_atRNASE43.7314q11.1Ribonuclease, RNase A family, 4
 38691_s_atSFTPC−3.198p21Surfactant, pulmonary-associated protein C
 215704_atFLG−5.851q21Filaggrin
  • a 5-Aza-dC, 5′-aza-2′-deoxycytidine; NB, neuroblastoma; EGF, epidermal growth factor.

  • b Positive (+) fold change indicates genes up-regulated in the 5-Aza-dC treated NB cell line. Negative (−) fold change indicates genes down-regulated in the 5-Aza-dC treated NB cell line.