Table 2

Effects on ligand-induced phosphorylation in cell-based ELISA assaysa

CompoundEGFRbErbB2KDRPDGFR
A431 cellsBT-474 cellsCHO cellsA31 cells
IC50m] ± SE
AEE7880.011 ± 0.050.22 ± 0.040.96 ± 0.25> 10
n = 3n = 9n = 6n = 3
  • a Mean ± SE, n = number of experiments.

  • b EGFR, epidermal growth factor receptor; PDGFR, platelet-derived growth factor receptor; CHO, Chinese hamster ovary.