Table 1

Cytotoxicity of BN80927, SN38, and VP-16a in a panel of nine human tumor cell lines

TissueCell lineIC50, nm [95% confidence interval]
BN80927SN38VP-16
BreastMCF748318100,000
[20–120][88–1300]
ColonHT29211064,500
[11–38][80–140][2,200–10,000]
ProstateDU1453181,300
[1.6–6][12–25][410–4,000]
PC381126> 10,000
[44–156][84–192]
OvarySKOV313394,900
[10–16][24–65][1,400–23,000]
BladderT242.24.62,700
[1.2–4.2][3.6–6.0][1,200–5,500]
LeukemiaHL607.48.41,300
[1.8–30][1.1–64][80–8,000]
K5628.49.21,400
[5–14][6–14][640–3,140]
LungA5491761> 10,000
[7.5–40][33–112]
  • a VP-16, etoposide.