Table 2

Cytotoxicity against pairs of resistant and sensitive cell lines

Cell line pairs (Resistance inducer)CompoundsIC50, nmRfaIC50R:C50S
ResistantSensitive
T24anp/T24BN809272.92.21
(Pgp)SN38104.62
adr3102016
VP-16247026401
K562adr/K562BN80927188.42
(Pgp)SN38359.24
adr50305.3100
VP-1614700143010
HL60adr/HL60BN809271.37.40.2
(mrp)SN38108.41.2
adr360018200
VP-16740012606
HL60dnr/HL60BN80927327.44
(Pgp)SN38838.410
dnr199011180
VP-1644000126035
  • a Rf, resistance factor [defined as the ratio of the IC50 value obtained with the resistant cell line (IC50R) to the one obtained with parent cell line (IC50S)]; anp, Adriamycin, navelbine, and PE1001; Pgp, P-glycoprotein; adr, adriamycine; mrp, multidrug resistance-associated protein; dnr, daunorubicin.