Table 3

Cytotoxicity against topoisomerase I (Topo I) inhibitor-resistant cell line

Cell line pairsCompoundIC50, nmRfaIC50R:IC50S
ResistantSensitive
KB-STP2/KBBN80927230902.6
(T1 down-regulated)SN3830003309
VP-16560031001.8
  • a Rf, resistance factor [defined as the ratio of the IC50 value obtained with the resistant cell line (IC50R) to the one obtained with parent cell line (IC50S)]; VP-16, etoposide.