Table 1

aOR of breast cancer development associated with having one additional high-risk genotype of the five NHEJ genes (Ku70, Ku80, DNA-PKcs, XRCC4, and Ligase IV), stratified by BRCA1 genotypea

Genotypes of BRCA1 Glu1038GlyCases (%)Controls (%)aOR (95% CI)b
Glu/Glu 179 (38.2)265 (35.9)1.04 (0.83–1.30)
Glu/Gly, Gly/Gly 290 (61.8)473 (64.1)1.28 (1.06–1.53)
  • a aOR, adjusted odds ratio; NHEJ, nonhomologous end-joining; CI, confidence interval.

  • b The aOR of breast cancer development associated with the number of high-risk genotypes of NHEJ genes was calculated in a multivariate logistic regression model containing the number of high-risk genotypes (5 versus 4, 4 versus 3, 3 versus 2, 2 versus 1, and 1 versus 0), age, a family history of breast cancer, reproductive risk factors, body mass index, and a history of hormone replacement therapy.