Table 1

PIK3CA mutations in brain tumors

PIK3CA mutationsaBrain tumorsbTotal
ExonNucleotideAmino acidAnaplastic oligodendrogliomaGlioblastoma multiformeMedulloblastomaAnaplastic astrocytomaLow-grade astrocytomaEpendymoma
Exon 9G1624AE542K1c12
Exon 9G1633AE545K1c2c14
Exon 9A1637CQ546P11
Exon 20T3061AY1021N1c1
Exon 20A3140GH1047R1c113
Exon 20A3140TH1047L1c1
Exon 20C3193TH1065Y11
Tumors with mutations35410013
No. samples screened2110578312426285
Percent of tumors with mutations14%5%5%3%0%0%5%
  • a Exon number with nucleotide and amino acid change resulting from mutation.

  • b Number of nonsynonymous mutations observed in indicated tumors.

  • c Corresponding normal tissue were available.