Table 2

Percentage of CpG island hypermethylation in mouse and human cancer samples for the identified new target genes

MouseHuman
Mouse skin tumor cell lines (n = 10)Mouse skin primary tumors (n = 15)Human cancer cell lines (n = 28)Human primary tumors (n = 109)
Papilloma (n = 5)Squamous carcinoma (n = 5)Spindle carcinoma (n = 5)Nonmelanoma skin tumors (n = 26)Other tumors (n = 83)
IGFBP3 3/10 (30%)0/52/5 (40%)4/5 (80%)17/28 (60.27%)3/25 (12%)37/65 (57%)
CMKAR4 8/10 (80%)0/51/5 (20%)1/5 (20%)10/28 (36%)8/26 (31%)9/70 (13%)
PRDX1 3/10 (30%)0/50/51/5 (20%)4/28 (14%)14/24 (58%)2/74 (3%)
CSRP2 1/10 (10%)0/50/40/54/28 (14%)6/24 (25%)11/70 (16%)