Table 1

Percentage inhibition of SW480 and RKO colon cancer cell growth (6 days) by rosiglitazone and PPARγ-active C-substituted DIMs

Treatment (μmol/L)SW480RKO
Rosiglitazone
 17.85 ± 0.920.39 ± 1.73
 58.13 ± 1.342.79 ± 2.89
 107.75 ± 2.212 ± 1.55
DIM-C-pPhCF3
 122.35 ± 3.87*4.36 ± 0.18
 5104.83 ± 0.29*101.65 ± 0.06*
 10104.93 ± 0.25*101.71 ± 0.09*
DIM-C-pPhtBu
 11.43 ± 3.473.22 ± 1.70
 565.52 ± 1.85*41.04 ± 1.76*
 10102.03 ± 0.37*103.82 ± 0.06*
DIM-C-pPhC6H5
 12.184 ± 2.446.34 ± 2.20
 524.328 ± 1.67*39.77 ± 2.33*
 10103.91 ± 0.08*102.83 ± 0.052*
  • NOTE. Cells were treated with different concentrations of the test compounds, and cell numbers were determined as described in the Materials and Methods, and the percent inhibition of cell growth was compared with DMSO (set at 100%). Results are means ± SD for three replicate determinations for each treatment group, and significant (P < 0.05) inhibition (*) is indicated.