Table 1

Clinicopathological data from the series of patients stratified by CITED4 nuclear immunopositivity

	CITED4 nuclear-negative (N = 124)	CITED4 nuclear-positive (N = 162)	P
Age (years)
<50	38	43	0.45
≥50	86	119
Nodal status
negative	68	88	0.96
positive	56	74
Tumor size
≤2 cm	57	96	0.03^∗
>2 cm	67	66
ER
negative	47	47	0.11
positive	77	115
EGFR
negative	51	60	0.48
positive	70	98
Grade
I	16	31	0.0001
II	27	54
III	49	29
CVC
<7	12	22	0.04^∗
≥7	19	12
HIF-1α tumor
negative	81	123	0.05^∗
positive	29	24
VEGF-A
negative	58	83	0.50
positive	57	69

NOTE: Where n < 286 data unavailable.
Abbreviations: ER, estrogen receptor; EGFR, epidermal growth factor receptor; CVC, Chalkley vessel count; HIF, hypoxia-inducible factor.
∗ , significant.