Table 3

egfr genotype frequencies and odds ratios for breast cancer overall and by family history of breast cancer

Negfr genotypesaPb
ssslll
N (%)N (%)N (%)
OverallControls1063516 (48.8)445 (41.9)102 (9.6)0.64
Cases604279 (46.2)266 (44.0)59 (9.8)
ORc (95% CI)1.01.19 (0.96–1.48)1.13 (0.78–1.62)
By family history
No family historyControls1004480 (47.8)424 (42.2)100 (10.0)0.43
Cases528242 (45.8)240 (45.4)46 (8.7)
ORd (95% CI)1.01.17 (0.93–1.47)0.95 (0.65–1.40)
Positive family historyControls5936 (61.0)21 (35.6)2 (3.4)0.04
Cases7637 (48.7)26 (34.2)13 (17.1)
ORd (95% CI)1.01.79 (0.70–4.57)10.43 (1.85–58.70)
Case-only analysisNo family history528242 (45.8)240 (45.5)46 (8.7)0.03
Positive family history7637 (48.7)26 (34.2)13 (17.1)
ORe (95% CI)1.00.72 (0.42–1.24)1.83 (0.90–3.72)
  • a Genotypes according to a short (≤18 CA repeats) and a long (≥19 CA repeats) allele: ss (short/short), sl (short/long), ll (long/long).

  • b P of the χ2 test of the genotype distribution.

  • c Adjusted for number of full-term pregnancies (0, 1–2, ≥3), age at menarche (≤12, ≥13 years), duration of breastfeeding (continuous), menopausal status, and family history, alcohol consumption (0, ≤18, or ≥19 g/day). OR, odds ratio; CI, confidence interval.

  • d Adjusted for number of full-term pregnancies (0, 1–2, ≥3), age at menarche (≤12, ≥13 years), duration of breastfeeding (continuous), menopausal status, alcohol consumption (0, ≤18, or ≥19 g/day).

  • e Case-only analysis. Odds ratio adjusted for number of full-term pregnancies (0, 1–2, ≥3), age at menarche (≤12, ≥13 years), duration of breastfeeding (continuous), menopausal status, alcohol consumption (0, ≤18, or ≥19 g/day).