Table 2

Rank list of proteins with >1.5-fold increase during hypoxia along with the corresponding mRNA change

ProteinSwiss Prot IDmRNA inductionFunctionFold protein
MKK3bP97293-2.3Response to stress; regulation of cell proliferation>10*
HIF-1αQ16665-1.9Transcription factor; protein binding13.7
Dihydrofolate reductaseP00376-4.3dTMP biosynthesis; response to chemotherapy10.6
PaxillinP49024-1.0Adaptors; tyrosine kinase substrates4.0
Binder of ARL 2Q9Y2Y0-2.2Cytoskeleton, GTPases; GTPase regulators3.4
MoesinP26038-1.2Nitric oxide, mitochondria3.2
SNX1Q135961.2Endosome to lysosome transport; endocytosis2.9
JunP056274.0Tyrosine kinases; cell cycle control2.8
Transcription termination factor IQ15361-2.2Nuclear transport2.4
IKKβO149201.2Activation of NF-κB pathway2.2
Nuclear transport factor 2P13662-1.8Nucleocytoplasmic transport; protein-nucleus import2.2
P150gluedP28023-1.4Axon cargo transport; neurogenesis; mitosis2.2
p53P13481-1.2Apoptosis; negative regulation of angiogenesis2.2
EnolaseP067331.6Glycolytic enzyme2.0
Neuronal pentraxinQ15818-3.9Cell adhesion; cytoskeleton2.0
Kip1/p27P464141.5Regulation of cell cycle1.9
HSP27P047921.4Response to oxidative stress1.8
Density-regulated protein 1O43583-4.4Cell communication; regulation of cell growth1.8
Highly expressed in cancerO14777-2.1G2-M transition of mitotic cell cycle1.7
CortactinQ14247-1.3Actin cytoskeleton organization and biogenesis1.5
  • NOTE. The lack of correlation between protein and mRNA induction within these genes suggests hypoxia-regulated gene expression may be significantly influenced by posttranscriptional mechanisms.

  • * Exact fold induction unable to be determined because normoxic signal below threshold of detection.