Table 1

Fluoxetine effects on the cytotoxicity of chemotherapeutic drugs, in drug-sensitive and in drug-resistant cells

Cell lineMitomycin CDoxorubicinVinblastine
IC50*m)RFIC50m)RFIC50m)RF
DrugDrug + fluoxetineDrugDrug + fluoxetineDrugDrug + fluoxetine
MCF-730281.10.350.330.90.280.301.1
P388/WT45421.14.74.81.14.24.41.0
HT2930330.93.63.30.93.53.31.1
B16F10.92093.658120.7829130.4515
D1222093.363190.9021211.021
C-261052.542250.84369.10.2530
MCF-7/ADR2004.544190.2969220.3266
P388/ADR2245.442310.5527381.456
  • * The IC50 value was determined for each cell line after exposure to a series of drug concentrations with/without 15 μm fluoxetine, using the transient protocol. SD values were <5% of the IC50 value (n = 5).

  • RF represents fold-change in drug sensitivity.