Table 3

Genes for which expression is increased in DU-145 wtBRCA1 [versus control (Neo)] cell clones

Accession no.Gene nameSymbolRatioRatio
Mean ± SE (Range)Affymetrix oligonucleotide array (N = 1)
Transcription/Nuclear proteins
 AA969184Cytokine inducible nuclear protein (= cardiac ankyrin repeat protein)CARP10.1 ± 4.6 (3)
 H45711Zinc finger transcription factor hEZFEZF3.4 ± 1.2 (2)
 AA115076Human msg1-related gene 1 (mrg1) mRNAMRG12.9 ± 0.3 (2)
 T72202Transcription factor IL-4 Stat (also known as Stat6)STAT62.7 ± 0.2 (3)
 AA425238Proto-oncogene AML1 {alternative products}CBFA22.6 ± 0.3 (3)6.1
 AA911236v-Myb avian myeloblastosis viral oncogene homologue-like 1 (= AMYB)MYBL12.6 ± 0.2 (3)13
 N66177Microphthalmia-associated transcription factorMITF2.6 ± 0.3 (2)2.8
 H96235v-Ets avian erythroblastosis virus E26 oncogene homologue 2ETS22.4 ± 0.1 (2)12
Stress response: oxidative stress and xenobiotic detoxification
 AA495936GST, microsomal 1MGST110.2 ± 4.4 (3)
 AA670438Ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)UCHL18.2 ± 4.0 (2)18
 AA455538NAD(P)H:menadione oxidoreductase (also called NQO1)NMOR13.8 ± 0.9 (3)4.6
 AA680300Member of PAS protein 2 (MOP2, also called HIF2α)MOP23.4 ± 0.5 (3)
 W73474GST, microsomal 2MGST23.3 ± 1.3 (2)5.2
 N93686Aldehyde dehydrogenase 7ALDH73.2 ± 0.4 (2)
 AA625806Ninjurin1 (nerve injury-induced protein 1)NINJ12.7 ± 0.3 (4)
 AA677655Klotho proteinKL2.6 ± 0.5 (2)
 H99813GST θ1GSTT12.5 ± 0.2 (3)2.3
 AA664180Glutathione peroxidase 3 (plasma)GPX32.4 ± 0.5 (2)5.3
 AA453859Alcohol dehydrogenase 5 (χ subunit, class III)ADH52.3 ± 0.4 (3)
 AA446301Paraoxonase (PON2 protein)PON22.3 ± 0.4 (3)
 AA428859Glutathione transferase ζ 1 (GSTZ1)GSTZ12.1 ± 0.1 (2)
 H99699Aconitase 2, mitochondrialACO22.0 ± 0.1 (2)
 H21041Activating transcription factor 3ATF31.9 ± 0.3 (2)
Replication/Cell cycle/DNA repair and metabolism
 R603435′; nucleotidase (CD73, placental purine ecto-5′-nucleotidase)NT5E6.2 ± 2.9 (3)
 AA429895Human multidrug resistance-associated protein homologue (MRP3)MRP32.6 ± 0.1 (2)
 AA931758Putative lymphocyte G0-G1 switch gene (G0S2)G0S2A2.6 ± 0.4 (4)
 N72115Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)CDKN2C2.6 ± 0.5 (2)2.3
 H85464Deleted in split hand/split foot syndrome 1 (DSS1)DSS12.5 ± 0.3 (2)2.2
 AA430382Nucleoside phosphorylaseNP1.9 ± 0.0 (2)
Signal transduction
 AA598601Insulin-like growth factor binding protein 3IGFBP35.3 ± 1.3 (2)2.1
 T72877Interleukin 1 receptor antagonistIL1RN4.0 ± 1.6 (3)
 AA460286G protein γ-10 subunit (guanine nucleotide-binding protein GBGA)2.4 ± 0.3 (3)
 H26426Protein tyrosine phosphatase, receptor type, mu polypeptidePTPRM2.4 ± 0.4 (2)2.9
 AA460841Insulin receptor substrate-1 [human, skeletal muscle, mRNA, 5828 nt]IRS12.3 ± 0.3 (3)6.1
 AA443302Rho-related GTP binding protein RhoERHOE2.1 ± 0.2 (2)4.9
 AA411640Ras-related GTP-binding protein A (ragA protein)RAGA2.1 ± 0.3 (2)
 T57556Putative protein kinase C inhibitor PKCI-1 (protein kinase C-interacting 1)PRKCNH11.9 ± 0.0 (2)
 AA910443Nephroblastoma-overexpressed geneNOV1.7 ± 0.2 (2)2.3
Biosynthesis and metabolism
 H87471Human l-kynurenine hydrolase (kynureninase)KYNU4.0 ± 1.5 (2)5.3
 AA401111Glucose phosphate isomeraseGPI4.4 ± 0.6 (4)
 AA424937Glucose-6-phosphate dehydrogenaseG6PD3.1 ± 0.6 (2)2.1
 AA599158Multifunctional aminoacyl-tRNA synthetaseSYHUQT2.9 ± 0.3 (2)
 AA894557Creatine kinase BCKB2.9 ± 0.9 (2)3.4
 H44956Fumarylacetoacetate hydrolaseFAH2.9 ± 0.2 (4)
 AA011215Spermidine/spermine N1-acetyltransferaseSAT2.8 ± 0.4 (3)
 T71782Branched chain Acyl-CoA oxidaseBRCOX2.7 ± 0.1 (2)7.3
 AA669689Malate oxidoreductase (NADH-dependent malic enzyme)2.5 ± 0.3 (4)3.7
 AA485653Mannosyl (α-1,6) glycoprotein-β-1,2-N-acetylglucosaminyltransferase IIMGAT22.4 ± 0.0 (4)2.7
 W07099N-acetylglucosaminidase, α- (Sanfilippo disease IIIB)NAGLU2.3 ± 0.1 (2)
 AA444009Acid α-glucosidaseGAA2.3 ± 0.5 (2)
Growth factor/Cytokine and receptors
 H15718XL receptor tyrosine kinaseAXL5.1 ± 3.1 (2)99
 T55558Colony-stimulating factor 1 (M-CSF)CSF13.2 ± 0.6 (3)3.4
 AA262988Brain-derived neurotrophic factorBDNF3.0 ± 0.1 (2)23
 R19956Vascular endothelial growth factorVEGF2.6 ± 0.6 (3)
 N31467Coxsackie virus and adenovirus receptorCXADR2.6 ± 0.3 (2)2.3
 AA504461Low-density lipoprotein receptor precursorLDLR2.6 ± 0.0 (2)2.3
 T56316Nerve growth factor βNGFB2.2 ± 0.2 (2)17
 AA053285Interleukin 15 receptor α chainIL15RA2.2 ± 0.2 (3)2.6
 AA453831Hepatoma-derived growth factorHDGF2.1 ± 0.0 (2)
 T47813Macrophage-stimulating 1 (hepatocyte growth factor-like)MST11.9 ± 0.2 (2)
Cytoskeleton/Cell adhesion/Cell and organelle structure
 H15662Cytoplasmic linker 2CYLN24.2 ± 1.3 (2)
 H15662Cytoplasmic linker 2 isoform 2 (Williams Beuren syndrome) [KIAA0291]4.1 ± 1.1 (2)
 R78725Vitamin A responsive; cytoskeleton relatedJWA3.3 ± 0.8 (2)2.8
 AA490684Non-lens β γ-crystallin like [absent in melanoma 1 (AIM1)]AIM13.1 ± 0.3 (2)36
 R06417Junction plakoglobinJUP2.6 ± 0.6 (3)
 R13558Activated leucocyte cell adhesion moleculeALCAM2.6 ± 0.5 (2)31
 H50993Actinin, α 4ACTN42.1 ± 0.2 (2)2.1
Extracellular matrix
 T77595Hexabrachion (tenascin C, cytotactin)HXB6.8 ± 4.4 (2)10
 AA677534H. sapiens mRNA for laminin4.8 ± 2.0 (3)
 AA001432Laminin, α 3 [nicein (150 kDa), kalinin (165 kDa), BM600 (150 kDa), epilegrin]LAMA32.7 ± 0.5 (3)39
 AA427561Heparan sulfate proteoglycan (HSPG2)HSPG22.6 ± 0.2 (3)