Table 5A

Continued

Accession no.Gene name (symbol)Ratio (wtBRCA1/control)
DU-145MCF-7 (−E2)MCF-7 (+E2)
 Differentiation/Development/Tissue-specific expression
  AA402207Eyes absent homologue (EAB1, EYA2)2.6 ± 0.6 (3)3.0 ± 1.0 (2)
  R26960Peripheral myelin protein 22 (PMP22)2.0 ± 0.2 (2)2.1 (1)2.8 ± 0.8 (2)
  AA464250Keratin 19 (KRT19)2.5 ± 0.4 (4)1.8 ± 0.2 (2)
  AA676598Nerve growth factor-inducible PC4 homologue (IFRD2)1.9 ± 0.2 (3)1.8 ± 0.2 (2)
 Channels/Pore structure/Transport
  R39446WHITE protein homologue2.4 ± 0.8 (2)
  N62620Two P-domain K+ channel (TWIK1)3.5 ± 1.2 (2)1.5 ± 0.0 (2)
 RNA or protein processing/Protein modification
  W73874Cathepsin L (CTSL)2.6 ± 0.3 (2)
  AA490124Ubiquitin conjugating enzyme E2 (Drosophila bandless) [UBE2N]2.1 ± 0.3 (2)
  AA011215Spermine/spermidine N1-acetyltransferase (SAT)2.8 ± 0.4 (3)2.0 ± 0.1 (2)
  AA459039Placental bikunin (serine protease inhibitor) [SPINT2, HAI2]2.0 ± 0.2 (3)
  AA628430Sm-like protein CaSm (LSM1)2.6 ± 0.1 (4)1.7 ± 0.2 (2)
 Miscellaneous or function unknown
  AA418918Nuclear autoantigen GS2NA (striatin-3) [GS2NA]3.4 ± 0.7 (3)2.2 ± 0.2 (2)
Decreased by BRCA1
 Transcription factors/Nuclear proteins
  H32858X2 box repressor (putative zinc finger transcriptional regulator)0.43 ± 0.13 (2)
  N67262Zinc finger protein 135 (clone PH8-17) [ZNF135]0.51 ± 0.17
  N49526Myb proto-oncogene (MYB)0.52 ± 0.20
  AA704809SIL [TAL1 (SCL) interrupting locus] (hypoxia-sensitive) [SIL]0.40 ± 0.09 (2)0.64 ± 0.08 (2)
 Stress response/Xenobiotic detoxification/Mitochondrial function
  AA099134Oxygen-regulated protein, 150 kDa (ORP150)0.40 ± 0.11 (2)0.41 ± 0.22 (2)
  AA133187Iron-regulated protein (IRP2, IREB2)0.42 ± 0.25 (2)
  N55459Metallothionein hMT-1f (functional) [MT1F]0.69 ± 0.05 (2)0.50 ± 0.06 (2)
  AA621218Carnitine acetyltransferase (CRAT)0.58 ± 0.05 (3)
  N66957Cytochrome P450 subfamily XXVII (CYP27, CYP27A1)0.66 ± 0.06
 Signal transduction
  AA284634Janus kinase 1 (JAK1)0.32 ± 0.09 (3)0.34 ± 0.13 (3)0.50 ± 0.22 (2)
  AA282196Homo sapiens serine/threonine protein kinase0.40 ± 0.23 (2)0.56 ± 0.01 (2)
  AA101793Lipid-activated, protein kinase 2 (PRK2)0.43 ± 0.06 (3)0.43 ± 0.11 (2)
  AA418999Smad5 (a MAD-like protein) [SMAD5]0.40 ± 0.04 (2)0.50 ± 0.18 (2)
 Biosynthesis and metabolism
  AA070357Transketolase (Wernicke-Korsakoff syndrome) [TKT]0.29 ± 0.07 (3)
  R84263CAD protein (multifunctional enzyme) (CAD)0.46 ± 0.23
  AA018372Liver glutamate dehydrogenase (GLUD1)0.36 ± 0.12 (2)0.53 ± 0.17 (2)
 Growth factor/Cytokine and receptors
  AA425028Human cytokine receptor EBI3 (EBI3)0.35 ± 0.05 (2)0.61 ± 0.05 (2)
  AA019320Adducin 2 (β) [ADD2, ADDB]0.65 ± 0.08 (3)0.41 ± 0.07 (2)
 Cytoskeleton/Cell Adhesion/Cell structure
  AA598659NuMA (nuclear matrix protein) [NUMA, NUMA1]0.20 ± 0.12
  W31983X104 (tight junction protein 2, zona occludens 2) [TJP2, ZO2]0.32 ± 0.17 (2)0.59 ± 0.09 (2)
  W13290Tight junction protein 1 (TJP1)0.45 ± 0.14 (3)
  AA455062Zyxin (YX)0.48 ± 0.16 (3)
  AA669758Nucleophosmin (B23, numatrin) [NPM1]0.38 ± 0.01 (2)0.58 ± 0.14 (2)
  AA452566Peroxisomal membrane protein 3 (XMP3)0.46 ± 0.00 (2)0.69 ± 0.01 (2)
 Extracellular matrix
  AA464630Thrombospondin 1 (HBS1)0.50 ± 0.13 (3)0.41 ± 0.16 (2)
  H24650Laminin γ 1 (AMC1)0.49 ± 0.16 (3)0.46 ± 0.18 (2)
  W93163TNF-inducible protein 6 (TSG-6) [TNFAIP6]0.24 ± 0.10 (3)0.70 ± 0.01 (2)
 Apoptosis/Cell death
  AA476272Putative DNA-binding protein A20 (TNFα-induced) [TNFAIP3]0.56 ± 0.05 (2)
 Differentiation/Development/Tissue specific
  AA455145Semaphorin V (guidance of neuronal growth cones) [SEMA3B]0.64 ± 0.09 (2)
 Channels/Pore structure/Transport
  AA457050Treacher-Collins syndrome susceptibility-1 (treacle) [TCOF1]0.50 ± 0.07
  N46843Aquaporin 4 (AQP4)0.66 ± 0.01
 RNA or protein processing/Protein modification
  AA284634Antithrombin III [AT3, SERPINC1]0.25 ± 0.11 (2)
 Miscellaneous or function unknown
  AA05646554 kDa protein (RNP repeat domain protein)0.25 ± 0.06 (2)0.44 ± 0.23 (2)