Table 6

Selected genes whose expression is decreased in Brca1Δex11Δex (versus Brca1+/+) mouse embryo fibroblasts

Accession no.Gene nameSymbolRatio
Mean ± SE (range)Affymetrix Array (N = 1)
Transcription/Nuclear proteins
 AA208865Nuclear receptor corepressor 1Ncor10.47 ± 0.08 (2)
 AA276365Myocyte enhancer factor 2cMef2c0.47 ± 0.07 (2)0.44
 AA244944CCAAT/enhancer binding protein α (C/EBP), related sequence 1Cebpa-rs10.51 ± 0.02 (2)
 AA212695Trans-acting transcription factor Sp1 (cell cycle-regulated)Sp10.51 ± 0.09 (2)
 AA036347Kruppel-like factor 9Klf90.52 ± 0.11 (2)
 AA125037Zinc finger protein 148Zfp1480.52 ± 0.01 (2)
 AA138529Zinc finger protein 62Zfp620.56 ± 0.15 (2)
 AA501045Nuclear receptor subfamily 2, group H, member 2Nr2c20.56 ± 0.11 (2)0.061
 AA155377Zinc finger protein X linkedZfx0.57 ± 0.01 (2)
 W83524Transcription factor 12Tcf120.58 ± 0.06 (3)
 AA097341Nuclear receptor coactivator 1Ncoa10.59 ± 0.07 (3)
Stress response: oxidative stress and xenobiotic detoxification
 AA200734Ethanol decreased 2Etohd20.47 ± 0.07 (2)
 AA445861Activating transcription factor 2 (stress response transcription factor)Atf20.50 ± 0.07 (2)
 AA139271Glutathione peroxidase 3Gpx30.51 ± 0.05 (3)0.12
 W54349GST, α 1 (Ya)Gsta10.51 (1)
 AA120574Superoxide dismutase 1, solubleSod10.53 ± 0.07 (2)
 AA044475Nuclear factor, erythroid-derived 2, like 2 (also called Nrf2)Nfe2l20.53 ± 0.07 (2)
 AA033466MyeloperoxidaseMpo0.53 ± 0.06 (2)
 AA060716Early growth response 1 (stress-responsive transcription factor)Egr10.54 ± 0.16 (2)
 AA276440Selenoprotein P, plasma, 1Sepp10.57 ± 0.02 (3)
 W82873Aryl hydrocarbon receptorAhr0.59 ± 0.15 (2)
 AA250120GST, α 2 (Yc2)Gsta20.61 ± 0.10 (2)
Heat shock-related proteins
 AA212162Chaperonin subunit 8 (θ)Cct80.48 ± 0.12 (2)
 AA498713Heat shock protein, 74 kDaHsp740.58 ± 0.13 (2)
 W62018Heat shock cognate protein, 70Hsc700.61 ± 0.03 (2)
Replication/Cell cycle/DNA repair and metabolism
 AA17363Ectonucleotide pyrophosphatase/phosphodiesterase 2Enpp20.38 ± 0.22 (2)
 AA386895Tetratricopeptide repeat domain 3 (chromosome segregation)Ttc30.43 ± 0.07 (2)
 AA288567Suppressor of Ty 4 homologue (S. cerevisiae)Supt4 h0.44 ± 0.04 (3)
 AA268478Serine/threonine kinase 2 (homologous to mitotic egulator NIMA)Stk20.45 ± 0.03 (2)
 AA273291Chromodomain helicase DNA binding protein 1Chd10.47 ± 0.04 (3)
 AA498480Centrosomin ACsma0.49 ± 0.06 (2)
 AA542278ClusterinClu0.50 ± 0.04 (3)0.46
 AA122530SNM1 protein (required for repair of DNA double-strand cross-links)SNM10.55 ± 0.14 (2)
 AA285484G1 to phase transition 1Gspt10.55 ± 0.05 (2)
 AA4755685′-3′; exoribonuclease 2Xrn20.57 ± 0.05 (2)
 AW544661Serine/threonine kinase 10 (Polo-like kinase)Stk100.57 ± 0.18 (2)
 AA170792Topoisomerase (DNA) ITop10.58 ± 0.08 (2)
 AA108933CDC-like kinase (serine/threonine kinase, cell cycle regulatory)Clk0.58 ± 0.09 (3)
 AA020165Uridine phosphorylaseUpp0.59 ± 0.05 (3)
Signal transduction
 AA254238Rho-associated coiled-coil forming kinase 2Rock20.44 ± 0.11 (2)
 AA286039Ras-binding protein SUR-8 (also called suppressor of clear, Soc-2)Sur80.50 ± 0.02 (2)
 AA200336Tumor protein D52 (? Role in calcium-mediated signal transduction)Tpd520.51 ± 0.09 (2)
 AA177814MAD homologue (Drosophila) [also called Smad1]Madh10.52 ± 0.10 (2)
 AA271494Myristoylated alanine rich protein kinase CsubstrateMacs0.54 ± 0.14 (3)0.33
 AA124332Phosphodiesterase 8Pde80.57 ± 0.06 (2)
 AA413508SAPK/Erk/kinase 1Serk10.60 ± 0.01 (2)
 AA396114NET1 homologue member of Dbl family of Rho A GEFs)Net10.60 ± 0.02 (2)
Biosynthesis and metabolism
 AA068968Involved in GPI-anchor biosynthesisPig-b0.51 ± 0.08 (2)
 AA199988Mannosidase 1, alphaMan1a0.60 ± 0.08 (2)0.29
Growth factor/Cytokine and receptors
 AA020307Very low density lipoprotein receptorVldlr0.54 ± 0.15 (3)
 AA008515Transforming growth factor, β receptor IIITgfbr30.56 ± 0.01 (2)
 W53962Transforming growth factor, β 2Tgfb20.66 ± 0.05 (3)
Cytoskeleton/Cell adhesion/Cell and organelle structure
 W99951Neurofilament, light polypeptide (68 kDa)Nfl0.40 ± 0.03 (3)
 W13290Tight junction protein 1Tjp10.45 ± 0.00 (2)
 AA388122Maternal embryonic message 3 (vacuolar sorting protein 35)Mem30.45 ± 0.05 (2)
 AA009086Golgi autoantigen, golgin subfamily a, 4Golga40.49 ± 0.03 (2)
 AA021816Adducin 3 (γ) [membrane skeletal protein]Add30.56 ± 0.08 (3)
 AA060038Epsin 2 (involved in clathrin-mediated endocytosis)Epn20.58 ± 0.11 (3)
 AA472871Lysosomal membrane glycoprotein 2Lamp20.59 ± 0.11 (2)0.31
 AA274739Pinin (desmosome-associated and nuclear mRNA splicing protein)Pnn0.62 ± 0.07 (3)
Extracellular matrix
 AA239404NidogenNid0.48 ± 0.07 (2)
 AA059779Laminin, γ 1Lamc10.60 ± 0.03 (2)
 AA260280Procollagen, type III, α1Col3a10.68 ± 0.03 (2)0.12
Apoptosis/Cell death
 AA175651Caspase 11Casp110.38 ± 0.22 (2)
 AA098139Caspase 1Casp10.54 ± 0.09 (3)
Inflammation/Immune and antiviral response/histocompatibility
 AA174447IFN-activated gene 203Ifi2030.54 ± 0.02 (3)0.13
 AA189587Natural killer tumor recognition sequenceNktr0.59 ± 0.02 (3)