Table 1

Sphingomyelin enhances gemcitabine-induced mitochondrial depolarization, apoptosis, cell death, and ceramide formation in Panc1 cells

Gemcitabine *SM *MMP %Apoptosis %Cell death %pmol ceramide/nmole PO4
004.2 ± 3.23.6 ± 2.618.5 ± 7.00.46 ± 0.29
00.2 mg/ml8.8 ± 3.86.5 ± 3.823.7 ± 7.71.09 ± 0.42
100 nmol/L025.9 ± 9.619.9 ± 12.946.0 ± 4.20.59 ± 0.34
100 nmol/L0.2 mg/ml48.7 ± 7.442.1 ± 12.767.9 ± 9.71.58 ± 0.55
  • * Panc1 cells were treated with either 100 nmol/L gemcitabine and/or 0.2 mg/mL SM before measurement of MMP, apoptosis, cell death and ceramide.