Table 1

Inhibition of kinase activity by KU-55933 for ATM and related kinases

EnzymeIC50 (nmol/L)
ATM12.9 ± 0.1
DNA-PK2,500 ± 340
PI3K16,600 ± 1,700
mTOR9,300 ± 420
  • NOTE. The IC50 was calculated from sigmoid plots of increasing concentrations of KU-55933 versus activity for each of the kinases. Data represent the mean of five independent experiments ± SE.