Table 2

Survival of cell lines exposed to etoposide in the presence or absence of KU-55933

Survival (%)Sensitizer enhancement ratio
0 μmol/L KU-5593310 μmol/L KU-55933
LoVo24.5 ± 0.285.8 ± 0.34.2
SW62043.9 ± 0.12.3 ± 0.619.3
V324.5 ± 3.80.7 ± 0.436.5
V3YAC32.4 ± 1.31.8 ± 0.317.8
  • NOTE. Cells were preincubated with DMSO or KU-55933 for 1 hour before exposure to etoposide +/− KU-55933 for an additional 16 hours. Data are survival in the absence or presence of KU-55933 for approximately equipotent concentrations of etoposide (0.3 μmol/L for V3 and 1 μmol/L for LoVo, SW620, and V3YAC) ± SE (n = 3) normalized to DMSO control.