Table 1

Biological features associated with proliferation and apoptosis in colon cancers characterized for dysregulation in the APC/β-catenin/T-cell factor pathway

Total casesSurvivin expressionaApoptotic indexb median value (range)Proliferation indexc median value (range)
Median value (range)% of positive cases
β-Catenin negatived (microsatellite instability positive)1070 (0–100)80%0.6 (0–1.2)72.5 (50–100)
β-Catenin positive (microsatellite instability negative)6150 (0–90)74%0.4 (0–18.7)85.0 (50–100)
  • a Percentage of tumor cells with cytoplasmic immunostaining. Cut-off value for positive cases = 25% of positive cells.

  • b Percentage of tumor cells with cytoplasmic immunostaining for M30.

  • c Percentage of tumor cells with nuclear immunostaining for MIB-1.

  • d β-Catenin protein expression was evaluated on formalin-fixed, paraffin-embedded samples by immunohistochemistry (mouse monoclonal anti-β-catenin antibody; Transduction Laboratories, Lexington, KY) for the presence of nuclear, cytoplasmic, and membranous accumulation in both tumor and normal surrounding tissues.