Table 2

Prevalence and clinical importance of IgH translocations

AbnormalityMGUSa & SMM (%)MM (%)Up-regulated oncogenesEffect on prognosis
IgL translocations<20<20c-myc and othersUnknown
IgH translocations35–5050–70See belowMixed
t(4;14)(p16.3;q32)2–1015FGFR3 and MMSETAdverse
t(11;14)(q13;q32)15–3016Cyclin D1 and myeovFavorable
t(14;16)(q32;q23)2–55C-maf WWOX?Adverse
Cyclin D3, other or unknown, e.g., t(6;14)(p21;q32)Unknown4Cyclin D3, otherUnknown
 Other IgH10–1515–30mafB, MUM1, othersUnknown
  • a MGUS, monoclonal gammopathy of undetermined significance; MM, multiple myeloma; SMM, smoldering MM.