Table 1

Genes (n = 34) up-regulated by dexamethasone (Dex) and repressed by RU486 (RU) in three of three experiments

GenBank accession no.Gene productDex:Vehicle ratioaPDex-RU:Vehicle ratioaPb
Signal transduction
 S62539Insulin receptor substrate 1 (IRS-1)10.4 ± 2.90.022.5 ± 1.50.10
 X70340Transforming growth factor α (TGFα)9.6 ± 6.00.063.1 ± 2.10.37
 U07794Tyrosine kinase (TXK)9.5 ± 1.60.013.8 ± 2.80.14
 M60047Heparin-binding growth factor binding protein (FGFBP1)9.1 ± 4.50.051.0 ± 0.00.05
 X68277CL 100/protein-tyrosine phosphatase (MKP-1)6.4 ± 1.80.043.5 ± 1.40.08
 X75342SHB adaptor protein (a Src homology 2 protein)6.3 ± 2.90.063.7 ± 2.00.13
 U56387Proprotein convertase subtilisin/kexin type 5 (PCSK5)5.4 ± 2.30.082.0 ± 1.10.02
 U47011Fibroblast growth factor 8 (androgen-induced) (AIGF)4.9 ± 2.40.100.4 ± 0.30.01
 M22489Bone morphogenetic protein 2 precursor (BMP2A)3.6 ± 1.20.071.0 ± 0.40.15
 Y10032Serum and glucocorticoid regulated kinase (SGK-1)3.3 ± 0.70.031.8 ± 0.30.02
 M69043IκB-α (MAD-3/IκB-α)2.8 ± 0.40.021.4 ± 0.20.09
 M60974Growth arrest and DNA-damage-inducible, α (GADD45α)2.1 ± 0.10.011.4 ± 0.10.01
Metabolism related
 X63359UDP glycosyltransferase 2 family, polypeptide B10 (UGT2)16.1 ± 7.90.052.2 ± 1.20.03
 U37143Cytochrome P450, subfamily (CYP2J2)4.7 ± 0.40.031.7 ± 0.80.20
 AJ000503Dopachrome Δ-isomerase, tyrosine-related protein 2 (TYRP2)4.0 ± 1.80.112.4 ± 1.40.06
 L07765Carboxylesterase 1 (monocyte/macrophage serine esterase 1 (SES1)3.9 ± 2.20.192.7 ± 1.60.06
 X78669Calcium binding protein (ERC55)1.9 ± 0.30.041.1 ± 0.10.08
Transcription
 U78722Zinc finger protein 165 (LD65)2.3 ± 0.20.010.4 ± 0.20.06
 AF025770Zinc finger protein 189 (ZNF189)1.9 ± 0.20.040.7 ± 0.20.13
 AF003540Zinc finger protein 195 (znfp104)1.8 ± 0.10.011.1 ± 0.20.09
 X64318Nuclear factor, interleukin 3 regulated (NF-IL3A)1.6 ± 0.10.011.2 ± 0.10.01
Miscellaneous
 AJ01Tropinin T1, skeletal, slow (ANM)13.1 ± 6.20.091.0 ± 0.00.11
 AJ003125Cleavage of aminopropeptide of procollagens I, II and V (PCPN1)8.7 ± 5.70.122.9 ± 2.30.14
 AJ011733Synaptogyrin 4 (syngr4)3.1 ± 0.30.011.5 ± 0.30.01
 Y12851P2X7 receptor (P2X7)2.4 ± 0.30.021.5 ± 0.10.02
 AI865431ESTc14.8 ± 1.90.011.1 ± 0.10.02
 AI214965EST14.4 ± 4.70.013.7 ± 1.60.07
 AL050379EST6.8 ± 2.90.113.2 ± 1.60.21
 AA922934EST5.8 ± 2.90.090.9 ± 0.10.06
 AL049437EST5.1 ± 0.50.011.2 ± 0.20.01
 W27883EST5.0 ± 1.70.070.8 ± 0.30.12
 AI688740EST4.9 ± 2.60.130.5 ± 0.30.001
 AI635895EST3.3 ± 0.40.011.7 ± 0.30.09
 AI991631EST1.9 ± 0.20.031.0 ± 0.10.06
  • a The mean ratio (derived from GeneSpring 4.0) of expression intensity ± SE in three independent experiments.

  • b Dex/RU486 versus Dex.

  • c EST, expressed sequence tag.