Table 2

Genotype frequency of Toll-like receptor 4 (TLR4) single-2 nucleotide polymorphisms

SNPa (dbSNP)LocationAmino acidGenotypeSubjects, n (%)Pc
CasesControls
−2026A/GPromoterAA625 (45.45)341 (43.94)
AG596 (43.35)354 (45.62)
GG154 (11.20)81 (10.44)0.8
−1607T/CPromoterTT991 (72.07)571 (73.39)
TC350 (25.45)194 (24.94)
CC34 (2.47)13 (1.67)0.34
3622A/CIntronAA1228 (90.56)680 (88.66)
AC128 (9.44)82 (10.69)
CC0 (0.00)5 (0.65)0.07
3748A/CIntronAA1327 (96.02)747 (96.02)
AC53 (3.84)31 (3.98)
CC2 (0.14)0 (0.00)0.87
7449G/T (rs2149356)IntronGG603 (51.89)331 (52.62)
TG423 (36.40)224 (35.61)
TT136 (11.70)74 (11.76)0.83
8552A/G (rs4986790)CodingD299GAA1241 (90.06)693 (89.19)
AG136 (9.87)79 (10.17)
GG1 (0.07)5 (0.64)0.31
9615G/A (rs5030721)CodingGG1355 (98.12)766 (98.21)
AG25 (1.81)14 (1.79)
AA1 (0.07)0 (0.00)0.79
11381G/C3′-UTRGG1047 (75.87)625 (80.33)
CG318 (23.04)141 (18.12)
CC15 (1.09)12 (1.54)0.05
  • a SNP, single-nucleotide polymorphism; UTR, untranslated region.

  • b From ATG of Isoform A (NM_138554.1)

  • c Test for allele frequencies.