Table 2

Summary of the frequency of PTEN promoter hypermethylation in sporadic colorectal cancers and its relationship with TGFβRIIa mutational status

TGFβRII statusPTEN methylatedPTEN unmethylated
Mutation present7/10 (70%)b17/119 (14.3%)
Mutation absent3/10 (30%)102/119 (85.7%)
Total10/129 (7.8%)119/129 (92.3%)
  • a TGFβRII, transforming growth factor β receptor type II.

  • b The presence of PTEN promoter methylation significantly differed in tumors with and without TGFβRII mutation (Fisher’s exact test, P = 0.0003).