Table 3

Genes in which expression levels correlate with unfavorable survival in 35 medulloblastoma patients

Gene description (gene symbol)Image IDHazard ratioLower 95% CIaUpper 95% CIPExpression level
v-Ras neuroblastoma RAS oncogene homologue (NRAS)2721895.42.113.80.0002−1.6 ± 1.3
Protein phosphatase 2, regulatory subunit A (PPP2R1A)7700273.61.87.10.00031.5 ± 1.4
Mitogen-activated protein kinase 6 (MAPK6)1172383.41.77.00.00061.2 ± 1.7
O6-methylguanine-DNA methyltransferase (MGMT)1147604.11.610.50.0011.0 ± 1.3
N-Ethylmaleimide-sensitive factor (NSF)487945.41.716.90.0021.3 ± 1.5
Cytochrome P450, subfamily IVB, polypeptide 1 (CYP4B1)7248883.61.58.40.0021.4 ± 1.5
Interleukin 13 receptor, α 2 (IL13RA2)416483.51.58.30.0021.2 ± 1.4
Ras homologue enriched in brain 2 (RHEB2)3808523.21.56.50.002−1.2 ± 1.7
Death-associated protein 6 (DAXX)2149574.11.511.40.004−1.1 ± 1.3
Acetaldehyde dehydrogenase 1 (ALDH1A1)8408874.01.412.00.0041.2 ± 1.3
Chemokine (C-X-C motif) ligand 3 (CXCL3)15564333.61.58.70.0041.3 ± 1.4
Myeloproliferative leukemia virus oncogene (MPL)23404233.01.46.30.0041.0 ± 1.3
Minichromosome maintenance-deficient 5 (MCM5)1121152.71.35.60.004−1.7 ± 1.3
LIM homeobox protein 1 (LHX1)7732634.51.414.30.0051.1 ± 1.4
v-akt murine thymoma viral oncogene homologue 2 (AKT2)3406553.21.47.50.005−1.1 ± 1.3
Proteasome subunit β type 1 (PSMB1)4872413.61.49.00.0051.0 ± 1.5
Serine/threonine kinase 15 (STK15)8430972.61.06.80.005−1.3 ± 1.5
Aldehyde oxidase 1 (AOX1)1140433.91.510.60.0071.2 ± 3.2
Catenin (cadherin-associated protein), δ 1 (CTNND1)1093312.91.36.10.0071.2 ± 1.4
Cyclin-dependent kinase inhibitor 2D (CDKN2D)3607502.71.35.80.0071.0 ± 1.3
myc proto-oncogene protein (MYC)4172263.91.311.40.008−1.1 ± 1.3
Cyclin B1 (CCNB1)10327703.81.211.80.009−1.4 ± 1.4
Rho GDP dissociation inhibitor (GDI) α (ARHGDIA)7406283.61.210.50.01−1.5 ± 1.5
Nuclear factor I/B (NFIB)2646883.41.39.40.012.8 ± 2.1
Stathmin 1/oncoprotein 18 (STMN1)3668233.01.27.20.013.4 ± 1.8
ets variant gene 6 (ETV6)1119612.91.26.90.011.2 ± 1.5
SRY (sex determining region Y)-box 4 (SOX4)6693022.91.27.20.014.2 ± 2.5
Topoisomerase (DNA) II α (TOP2A)500512.81.26.50.011.2 ± 1.4
Nuclear factor of activated T cells (NFATC3)1546552.81.36.00.011.1 ± 1.3
Myeloid/lymphoid or mixed-lineage leukemia (MLL)7050004.21.115.30.021.3 ± 1.5
Gamma-aminobutyric acid A receptor, α 2 (GABRA2)217543.21.37.80.02−1.3 ± 1.4
Thrombospondin 2 (THBS2)2405923.01.27.90.021.1 ± 1.3
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, γ polypeptide (YWHAG)1369702.81.17.10.021.2 ± 1.4
Protein kinase, DNA-activated, catalytic polypeptide (PRKDC)2675932.81.17.10.02−1.4 ± 1.4
Mitogen-activated protein kinase 1 (MAPK1)1116782.81.17.10.021.2 ± 1.4
Inositol polyphosphate-5-phosphatase (INPP5D)7546112.81.26.60.021.0 ± 1.3
v-erb-b2 erythroblastic leukemia viral oncogene 3 (ERBB3)447082.81.26.40.021.3 ± 1.4
v-rel reticuloendotheliosis viral oncogene homologue (REL)7045482.71.16.60.021.1 ± 1.3
Retinoblastoma binding protein 1 (RBBP1)4900612.71.26.30.02−3.6 ± 1.6
Cyclin D1 (CCND1)7585252.71.16.60.021.1 ± 1.4
Tumor necrosis factor receptor superfamily (TNFRSF11A)3465442.61.16.10.021.0 ± 1.4
Nuclear receptor subfamily 4, group A, member 2 (NR4A2)384522.61.26.00.021.4 ± 1.4
Dual specificity phosphatase 9 (DUSP9)286782.61.16.20.021.1 ± 1.4
TEA domain family member 2 (TEAD2)46340962.91.17.70.03−2.1 ± 1.7
Tumor protein p53 (TP53)9243832.81.17.20.031.2 ± 1.3
Tubulin, γ 1 (TUBG1)1144332.71.07.10.031.3 ± 1.4
Neural cell adhesion molecule 1 (NCAM1)3668422.71.16.90.03−1.2 ± 1.2
Cyclin H (CCNH)7304112.61.06.60.031.6 ± 1.5
Nuclear factor related to κ B binding protein (NFRKB)1316262.61.16.00.031.3 ± 1.5
Cytochrome P450, subfamily IVA, polypeptide 11 (CYP4A11)1204663.51.011.80.041.2 ± 1.6
Antigen identified by monoclonal antibody Ki-67 (MKI67)1087183.01.09.10.043.9 ± 1.8
Kinesin family member (KIF17)15405792.91.08.50.041.0 ± 1.3
PMS2 postmeiotic segregation increased 2 (PMS2)5031152.81.08.10.041.1 ± 1.4
Cyclin-dependent kinase 8 (CDK8)428802.61.06.80.041.1 ± 1.2
  • a CI, confidence interval; expression level, mean expression level (medulloblastoma samples versus reference RNA pool) ± SD.