Table 2.

G+405C, C−460T, and C+936T polymorphisms of VEGF gene in association with breast cancer survival, the Shanghai Breast Cancer Study

VEGFCasesOverall survivalDisease-free survival
GenotypeEvents5-y survival % *HR (95% CI)Events5-y survival % *HR , (95% CI)
C−460T
    TT6149285.71.010780.81.0
    CT4177083.41.2 (0.8-1.6)7479.51.1 (0.8-1.4)
    CC881978.71.5 (0.9-2.5)2272.31.5 (1.0-2.4)
    Ptrend0.190.110.160.14
G+405C
    CC1912687.81.03977.51.0
    GC5067785.31.2 (0.8-1.8)7882.20.7 (0.5-1.1)
    GG3947880.31.6 (1.0-2.5)8376.71.0 (0.7-1.5)
    P0.030.020.100.48
C+936T
    CC74111485.01.013380.21.0
    CT3335983.11.2 (0.9-1.6)6079.31.0 (0.8-1.4)
    TT31679.81.3 (0.6-2.9)483.40.8 (0.3-2.2)
    Ptrend0.460.280.800.98
  • * Proportion of survival derived from Kaplan-Meier analysis.

  • Adjusted for age.

  • Subjects with missing information on disease relapse (n = 165) were excluded from this analysis.