Table 2.

A subset of the genes induced in atypical and malignant meningiomas

SAGE tag sequenceGene symbol (name) *Accession no. Fold increase
Cell cycle regulators §
    AAAGTCTAGACCND1 (cyclin D1)NM_053056
    ACATTTCCAAG0/S2 (putative lymphocyte G0/G1 switch gene)NM_01571418×
Cell adhesion and invasion
    AAGGGGGCAAITGB4 (integrin, β4)NM_00021310×
    GGGTAGGGTGITGA7 (integrin, α7)NM_00220616×
    CTGGGAGGAGTM4SF7 (transmembrane superfamily 4 member 7)NM_003271
    GCCGGGTGGGBSG (Basigin)NM_00172816×
Glycolysis and hypoxia
    GCGACCGTCAALDOA (aldolase A, fructose-bisphosphate)NM_000034
    TGGCCCCACCPKM2 (pyruvate kinase, muscle)NM_002654
Apoptosis
    GGGGGTGGATFASTK (Fas-activated serine/threonine kinase)NM_006712
    ACTGTAGAGTBcoR (Bcl6 interacting corepressor)NM_01774510×
    TGCCAGGACABOK (Bcl2-related ovarian killer)NM_03251512×
Signal transduction and transcription factors
    AGGAAGGAACERBB2 (v-erb-b2 avian erythroblastic leukemia viral oncogene)NM_004448
    TATGAGGGTARGS5 (regulator of G protein signaling 5)NM_00361722×
    CACTATATTTHES1 (hairy and enhancer of Split1)NM_005524
    TGGGGGCCGATLE2 (transducin-like enhancer of Split2)NM_00326014×
    GGATGTGGAGTLE3 (transducin-like enhancer of Split3)AB046767
    TGGCCCTCCASTAT6 (signal transducer and activator of transcription 6)NM_003153
  • NOTE: A few representative genes from each functional class that reflects a known phenotypic difference between benign and higher-grade meningiomas are shown. The meningioma SAGE libraries are posted at http://cgap.nci.nih.gov/SAGE.

    Components of the Notch signaling pathway that were induced in meningiomas are shown in boldface.

  • * HUGO/GDB nomenclature committee approved symbols for individual genes or are underlined if not yet available. Each gene sequence had a poly-A signal and/or poly-A tail and was matched to the SAGE tag.

  • The Genbank/RefSeq accession number that was used to identify the gene and contains the differentially expressed tag.

  • The fold increase is the ratio of SAGE tags in one of the three higher-grade meningiomas to nonneoplastic leptomeninges.

  • § Genes with potentially similar functions were grouped based on a review of publications and databases.