Table 3.

RR of Cox-2 and N-Tyr for smoking status, histology, and TP53 mutation status

Cox-2, n (%)Cox2+, n (%)RR * (95% CI)N-Tyr, n (%)N-Tyr+, n (%)RR * (95% CI)
Smoking status
    Never smokers (n = 40)17 (43.6)22 (56.4)1 (reference)19 (48.7)20 (51.3)1 (reference)
    Ever smokers (n = 91)32 (35.2)59 (64.8)1.7 (0.4-8.7)79 (88.8)10 (11.2)0.1 (0.02-0.6)
    Former smokers (n = 27)12 (44.4)15 (55.6)1.3 (0.3-7.3)22 (84.6)4(15.4) 0.2 (0.02-1.2)
    Current smokers (n = 64)20 (31.3)44 (68.8)2.1 (0.4-11)57 (90.5)6 (9.5)0.08 (0.01-0.5)
Histology
    Adenocarcinoma (n = 47)12 (25.5)35 (74.5)1 (reference)30 (65.2)16 (34.8)1 (reference)
    SCC (n = 54)23 (42.6)31 (57.4)0.3 (0.1-0.9)51 (96.2)2 (3.8)0.1 (0.03-0.8)
TP53 mutation status
    TP53 wild type (n = 47)16 (34.0)31 (66.0)1 (reference)30 (66.7)15 (33.3)1 (reference)
    TP53 mutated (n = 82)32 (39.5)49 (60.5)0.7 (0.3-1.6)66 (81.5)15 (18.5)0.8 (0.3-2.0)
  • * Multivariable analysis adjusted for age, sex and education (additional adjustment for smoking status in the analysis of histology and TP53 mutation).