Table 2.

Comparison of EGFR mutation, amplification, and expression

SampleHistologySNP data set *EGFR copy number (dCHIP)EGFR kinase domain mutation EGFR expression 1537_at EGFR expression 37327_at
S0480TSquamous120K14NoneN/AN/A
HCC827Adenocarcinoma120K14E746_A750delN/AN/A
AD347TAdenocarcinoma120K11None1,534.43699.58
H3255Adenocarcinoma60K8L858R4,059.731,913.25
H1819Adenocarcinoma120K4N/AN/AN/A
H1993Adenocarcinoma120K4N/AN/AN/A
S0405TAdenocarcinoma120K4E746_A750delN/AN/A
DFCI-LU-01Adenocarcinoma60K4L747_E749del, A750PN/AN/A
S0412TAdenocarcinoma120K3E746_A750delN/AN/A
S0514TAdenocarcinoma120K3G719SN/AN/A
S0380TAdenocarcinoma120K3E746_A750delN/AN/A
AD309TBAC120K3L747_E752del, P753S298.4831.54
AD157TAdenocarcinoma120K3None119.39104.56
AD337TAdenocarcinoma120K3None338.97221.75
H1975Adenocarcinoma60K3L858RN/AN/A
S0377TAdenocarcinoma120K2G719SN/AN/A
H358BAC120K2None183.3375.11
AD327TAdenocarcinoma120K2None94.5843.09
AD338TAdenocarcinoma120K2None127.8039.51
AD311TAdenocarcinoma120K2None33.5135.80
AD362TAdenocarcinoma120K2None48.2236.63
AD330TAdenocarcinoma120K2None44.8814.70
AD334TAdenocarcinoma120K2None31.6563.74
AD335TAdenocarcinoma120K2None24.2735.41
AD336TAdenocarcinoma120K2None132.1982.49
AD163TAdenocarcinoma120K2None29.6633.82
H1650Adenocarcinoma60K2None2,125.20640.89
H1666Adenocarcinoma60K2None600.01205.29
  • NOTE: Samples are those with EGFR amplification (copy number ≥ 4) or EGFR gene mutation or those with EGFR expression, EGFR copy number, and EGFR mutation status available. Abbreviation: N/A, not available.

  • * 120K set was from both XbaI and HindIII chips; 60K set was from only XbaI chip.

  • Ref. 12; Naoki et al., unpublished data.

  • Ref. 55; Naoki et al., unpublished data.