Table 3.

Significantly enriched (P < 0.01) GO terms within the interhistologic subtype-regulated genes (n = 687)

GO termGO IDChanged/totalPs
Biological process
    Lipid transport68699/490.0003
    Hormone metabolism424457/370.0013
        C21-steroid hormone metabolism82075/130.0002
    Lipid metabolism662929/3360.0012
        Steroid metabolism820212/880.0007
            Cholesterol metabolism82036/380.0074
    Copper ion homeostasis68783/50.0009
    Gonad development84065/180.0011
    Hormone biosynthesis424465/180.0011
        C21-steroid hormone biosynthesis67004/120.0017
    Chromatin assembly/disassembly63338/520.0025
        Nucleosome assembly63345/230.0035
    Lipid biosynthesis861014/1290.0025
        Steroid biosynthesis66947/420.0028
    Icosanoid metabolism66904/190.0100
        Prostanoid metabolism66923/80.0046
            Prostaglandin metabolism66933/80.0046
    Glycosylceramide metabolism66772/30.0062
    Phosphocreatine metabolism66032/30.0062
    Cell cycle arrest70504/170.0066
Cellular component
    Extracellular5576106/1,7060.0008
        Extracellular matrix557822/2430.0027
            Collagen55819/32<0.0001
            Sheet-forming collagen309352/20.0021
                Collagen type IV55872/20.0021
        Extracellular space561596/1,5410.0013
    Chromatin78510/810.0040
        Nucleosome7864/140.0031
        Nuclear heterochromatin57203/90.0067
    Clathrin coat of coated pit301323/80.0046
    Vesicular fraction425987/500.0077
        Microsome57927/500.0077
Molecular function
    Extracellular matrix structural constituent520111/55<0.0001
        Extracellular matrix structural constituent conferring tensile strength300208/30<0.0001
    Transferase activity, transferring alkyl or aryl (other than methyl) groups167656/390.0084
        Glutathione transferase activity43645/130.0002
    Galactosidase activity159253/40.0004
        β-Galactosidase activity45652/20.0021
    Intramolecular oxidoreductase activity168605/270.0072
        Intramolecular oxidoreductase activity, transposing C = C bonds168633/80.0046
            Steroid δ-isomerase activity47692/20.0021
        Prostaglandin D synthase activity46672/30.0062
    Oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor166572/20.0021
        GMP reductase activity39202/20.0021
    Carbonyl reductase (NADPH) activity40902/20.0021
    Steroid dehydrogenase activity162293/90.0067
        3-β-Hydroxy-δ5-steroid dehydrogenase activity38542/20.0021
    Reduced folate carrier activity85182/20.0021
    Heparin binding82017/400.0021
    Copper ion binding55076/300.0022
    Folic acid binding55423/70.0030
    Lipid transporter activity53196/340.0042
    Creatine kinase activity41112/30.0062
    Diphosphoinositol-polyphosphate diphosphatase activity84862/30.0062
    Cyclic AMP–dependent protein kinase regulator activity86033/90.0067
  • NOTE: Complete list and the actually dysregulated genes belonging to each of the GO terms can be found in Supplementary Table S2.