Table 5.

The most significantly enriched GO classes related to the 68 genes up-regulated or down-regulated genes in the pluripotent phenotype

GO termGO IDTotal genes in categoryOverexpressedUnderexpressedPs for enrichment
Imprinting63496DNMT3B, DNMT3L0.0003
Nuclear heterochromatin57209DNMT3B, DNMT3L0.0007
Nuclear chromatin79014DNMT3B, DNMT3L0.0018
Heterochromatin79216DNMT3B, DNMT3L0.0024
Large ribosomal subunit1593474MRPL18, RPL18A, RPL280.0047
Steroid binding549627HSD17B4HES10.0068
Chromosome5694165DNMT3B, DNMT3L, HUS1, TERF10.0068
Development72751,423ADORA2E, CD9, DNMT3B, DNMT3L, GAL, GDF3, HESX1, JARID2, LST1, POU5F1, SEMA6AHES1, WNT5A0.0090
G-protein-coupled receptor binding166435GALWNT5A0.0112
Cytosolic large ribosomal subunit584235RPL18A, RPL280.0112
Regulation of gene expression, epigenetic4002939DNMT3B, DNMT3L0.0138
Nuclear chromosome22839DNMT3B, DNMT3L0.0138
Neurogenesis7399317GAL, HESX1, POU5F1, SEMA6AHES10.0145
Steroid biosynthesis669442HSD17B4HES10.0159
Brain development742052HESX1, POU5F10.0238
Embryonic development9790142DNMT3L, POU5F1WNT5A0.0273
Protein targeting6605146HSD17B4, POU5F1PPP3CA0.0293
Embryonic morphogenesis979561POU5F1WNT5A0.0320
Ribosome5840154MRPL18, RPL18A, RPL280.0336
Structural constituent of ribosome3735154MRPL18, RPL18A, RPL280.0336
Cytosolic ribosome (sensu Eukarya)583064RPL18A, RPL280.0349
Nucleic acid binding36761,529APEH, DNMT3B, EIF4A1, HESX1, JARID2, NANOG, NARS, POU5F1, RPL18A, RPL28, TERF1HES10.0380
Central nervous system development741769HESX1, POU5F10.0401
Protein metabolism195381,589APEH, COX11, EIF4A1, FKBP4, HSD17B4, HUS1, NARS, PIM2, POU5F1, RPL18A, RPL28PPP3CA0.0494
  • NOTE: Only significant GO categories with at least two changed genes are shown.