Table 2.

Expression levels of hypoxia-related genes significantly up-regulated in sarcomas

Gene name *Probe set *Normal tissues (n = 14)Sarcoma samples (n = 38)P
Mean (SE)Mean (SE)
Hypoxia-inducible factor 1α200989_at1,836.41 (365.21)4,156.08 (300.10)<0.0001
PLOD2202620_s_at331.79 (78.89)1,370.68 (150.04)<0.0001
Annexin V200782_at3,108.48 (361.10)6,549.06 (462.77)<0.0001
BNIP3L221478_at743.54 (132.63)1,771.35 (122.75)<0.0001
Collagen 5 α1212489_at362.28 (86.24)3,071.91 (478.59)<0.0001
Vimentin201426_s_at10,351.16 (1,944.74)24,602.41 (1,579.80)<0.0001
Collagen 5 α1212488_at737.84 (188.65)5,286.67 (925.23)<0.0001
PLOD2202619_s_at393.69 (88.29)1,407.84 (203.68)<0.0001
Integrin 5α201389_at651.86 (74.55)1,662.48 (228.98)0.0001
Transforming growth factor β1201506_at1,946.11 (414.57)7,796.07 (1,471.60)0.0004
Solute carrier family 2 member 3202497_x_at204.72 (64.07)596.73 (99.83)0.0018
Insulin-like growth factor binding protein 3210095_s_at2,438.30 (632.27)5,521.79 (725.67)0.0025
Lysyl oxidase213640_s_at64.23 (24.92)200.56 (34.97)0.0026
CD99201028_s_at2,858.61 (362.11)4,630.09 (426.87)0.0028
Serpin E2212190_at1,115.58 (288.29)4,084.52 (937.73)0.0042
Placental growth factor209652_s_at122.10 (25.82)308.27 (56.46)0.0043
Angiopoietin 2205572_at69.36 (20.86)361.47 (96.21)0.0050
Serpin E1202627_s_at216.61 (43.90)1,056.07 (292.69)0.0072
Insulin-like growth factor 2202410_x_at128.86 (45.99)2,242.93 (769.49)0.0093
Adrenomedullin202912_at725.49 (98.20)1,365.18 (217.37)0.0100
Enolase 1217294_s_at1,947.34 (246.63)3,290.06 (439.80)0.0104
Insulin-like growth factor binding protein 3212143_s_at1,027.89 (230.20)1,939.46 (254.37)0.0111
Solute carrier family 2, member 3202499_s_at324.21 (70.52)672.62 (113.23)0.0119
Thioredoxin208864_s_at1,860.60 (281.47)2,834.88 (248.00)0.0138
Lactate dehydrogenase B201030_x_at4,954.59 (1,261.36)8,579.08 (648.90)0.0187
Lipocortin 1 (annexin 1)201012_at1,758.76 (930.27)4,566.52 (672.38)0.0211
Insulin-like growth factor 2210881_s_at83.61 (21.92)1,553.64 (610.10)0.0211
Lysyl oxidase204298_s_at216.29 (137.41)654.38 (119.32)0.0218
Phosphoglycerate kinase 1200737_at1,133.17 (121.11)1,777.04 (246.73)0.0233
VEGF-C209946_at218.49 (20.00)334.76 (45.69)0.0240
Thrombospondin 1201109_s_at269.66 (49.74)681.56 (171.80)0.0262
Transforming growth factor β3209747_at599.51 (123.44)1,182.97 (223.68)0.0267
Thrombospondin 1201107_s_at27.80 (7.22)74.88 (19.40)0.0277
  • * Some genes are represented by more than one probe set on the HG-U133A GeneChip.