Table 1.

Pdcd4 suppresses benign tumor outgrowth and malignant conversion rate

TumorsWild typeC1G6
Papillomas/mouse5.12.8 *1.8 *
Papilloma incidence88%73%64%
Carcinoma incidence
    (25 wk)16%6%0%
    (35 wk)57%25% 7%
Conversion frequency
    (25 wk)6%2%0%
    (35 wk)13%9%3%
Mice, n371614
  • NOTE: Mouse skin was initiated with a single application of DMBA (100 nmol), followed by twice weekly application of TPA (5 nmol) in 0.2 mL acetone for 26 weeks. Changes in papilloma and carcinoma development between Pdcd4-G6 and Pdcd4-C1 mice were compared to respective wild-type littermates.

  • * Two-sided P < 0.05 and P < 0.005 for comparison of papilloma burden between wild-type and C1 and wild-type and G6, respectively.

  • Two-sided P < 0.05 and P < 0.001 for comparison of carcinoma incidence between wild-type and C1 and wild-type and G6, respectively.

  • Two-sided P < 0.001 for comparison of conversion frequency between wild type and G6.