Table 1.

Primary and metastatic behavior of cancer cell lines

Cell linePrimary tumor latency (wk)Primary tumor frequency (%)Observed metastasis
Injection siteLocation
T.v.I.p.OrthoLungBone
SUM2294100
SUM1906-8100
SUM1496-8100++
SUM1592-4100++
SUM13158-12100++++
SUM225675++
HMLER6-885
HMLER-MMP96-880
HMLER-TGFβ4-6100
MCF7
MDA-MB-2316100++
MCF10A
PC-34-6100++++
  • NOTE: Tumor latency is defined by the time in which the tumor reached 1 cm in diameter. Five mice [bilateral injections (10 total sites) for breast cancer cells] were analyzed for each cell line. All cell lines were introduced into mice via tail vein (t.v.), i.p., or orthotopic (ortho) injection and examined for the presence (+) or absence (−) of metastases in the animals and the location of the respective metastases observed (lung or bone).