Table 2.

Sex- and age-adjusted associations between asthma polymorphisms and GBM from population-based Swedish case-control study (2000-2002), and comparisons with previously published associations between polymorphisms and asthma or inflammatory conditions

Gene (SNP)Previous asthma literatureGBM (present study)Previous asthma literature
Asthma, OR (95% CI)GBM, OR (95% CI)GBM, OR (trend test)GBM, cases *,n (%)GBM controls *,n (%)Asthma cases (%)Asthma controls (%)
IL-4RA (rs1805015, Ser478Pro)Asthma (14)Asthma (14)
    TT1.96 (1.13-3.44)1.001.0064 (59)288 (70)7763
    TC1.001.64 (1.05-2.55)1.7340 (37)107 (26)2033
    CC1.094 (4)16 (4)34
P = 0.07 (trend)
IL-4RA (rs1801275, Gln551Arg)Asthma (14)Asthma (14)
    AA1.25 (0.72-2.01)1.001.0053 (49)243 (60)6864
    AG1.001.61 (1.05-2.47)1.5245 (41)236 (34)2632
    GG2.0911 (10)24 (6)54
P = 0.02 (trend)
IL-13 (rs20541, Arg130Gln)Asthma (16)Asthma (16)
    GG0.48 (0.30, 0.76)1.001.0074 (67)254 (60)3654
    AG1.000.75 (0.48-1.17)0.8133 (30)144 (33)4839
    AA0.413 (3)24 (7)167
P = 0.12 (trend)
IL-13 (rs1800925, −1,112 C/T)Asthma (17)Asthma (17)
    CC0.51 (0.31-0.84)1.001.0084 (80)277 (69)5873
    CT1.000.56 (0.33-0.96)0.5518 (17)111 (28)3725
    TT0.643 (3)15 (4)52
P = 0.05 (trend)
ADAM33 (rs2280091, T1)Asthma (22)Asthma (22)
    TT0.24 (0.15-0.39)1.001.0082 (77)297 (71)5885
    TC1.000.82 (0.50-1.33)0.8524 (22)106 (26)3714
    CC0.562 (1)13 (3)61
P = 0.35 (trend)
COX-2 −765 GCC-reactive protein levels (26) *C-reactive protein (26)
    GG173.641.001.0080 (74)286 (72)75
    GC149.570.84 (0.45-1.57)0.9027 (25)105 (26)24
    CC0.521 (1)8 (2)1
P = 0.53 (trend)
  • * Differences in numbers of cases and controls among polymorphisms reflect failure to identify genotype for some DNA samples.

  • Numbers in parentheses are percentages of genotypes for GBM cases and controls excluding people reporting physician-diagnosed asthma or hayfever.

  • Papafili et al. ( 26) do not report C-reactive protein distribution of case group.