Table 1.

Vessel density in gelfoam induced by L3.6pl-conditioned media in the presence and absence of Src inhibition

Gelfoam/0.4% agarose with:Vessel density (CD31+), median (range)
Serum-free medium5 (0-30)
L3.6pl conditioned medium53 * (31-73)
L3.6pl + PP26 (0-33)
rIL-848 * (16-99)
rVEGF + rIL-841 * (31-104)
rVEGF + IL-8 + PP239 * (20-110)
  • NOTE: Gelfoam sponges containing different proangiogenic conditions were implanted s.c. in C3H/HeN mice. The sponges were harvested on day 14 and the number of CD31+ cells in 10 fields of 0.159 mm2 × 100 was determined.

  • * No significant differences were discernable among sponges containing proangiogenic conditions (P < 0.01).

  • Treatment with PP2 significantly inhibited angiogenesis induced by L3.6pl conditioned medium (P < 0.001, Mann-Whitney U test).