Table 2.

Upstate Kinase Profiler data for enzastaurin (LY317615.HCl, 1 μmol/L)

Kinase% Control activityKinase% Control activity
PKCβII11SAPK2b96
PKCα23SAPK2α101
PKCγ10SAPK388
PKCδ8SAPK497
PKC𝛉2JNK1α1107
PKCζ47JNK2α2103
PKCε9JNK385
PKCη53MAPK1114
PKCμ90MAPK2104
PKCι91AMPK91
IKKα107PRK288
IKKβ116Abl96
MEK191FGFR382
MKK699PDGFRα86
MKK7β102PDGFRβ100
PKBα75c-SRC101
PKBβ100BTK95
PDK181IGF1R94
p70S6K52EGFR102
  • Abbreviations: SAPK, stress-activated protein kinase; JNK, c-jun NH2-terminal kinase; MAPK, mitogen-activated protein kinase; MEK, MAPK kinase; EGFR, epidermal growth factor receptor; PDGFR, platelet-derived growth factor receptor; FGFR, fibroblast growth factor receptor.