Table 2.

Frequency of EGFR tyrosine kinase domain mutations in microdissected histologically normal bronchial and bronchiolar epithelium in lung adenocarcinoma patients

Cases/samplesMutated tumorsWild-type tumors
Exon 19 deletionExon 21 mutationTotal mutated
Patients by smoking status (n = 30)
    Never2 of 52 of 74 of 120 of 8
    Former4 of 60 of 14 of 70 of 8
    Current1 of 21 of 2
    Total patients7 of 13 (54%)2 of 8 (25%)9 of 21 (43%) *0 of 16 *
Foci by location compared with tumor (n = 90)
    Within8 of 14 (57%)1 of 7 (14%)9 of 21 (43%) 0 of 8
    Near (<5 mm)6 of 13 (46%)1 of 16 (6%)7 of 29 (24%) 0 of 13
    Distant0 of 90 of 50 of 14 0 of 5
Foci by respiratory structure (n = 90)
    Small bronchus8 of 17 (47%)1 of 9 (11%)9 of 26 (35%)0 of 10
    Bronchiole6 of 19 (32%)1 of 19 (5%)7 of 38 (18%)0 of 16
    Total foci14 of 36 (39%) 2 of 28 (7%) 16 of 64 (25%)0 of 26
  • * P value of comparison: 0.0046.

  • P value of comparison: 0.013.

  • P value of comparison: 0.021.