Table 2.

Meat intake and risk for colorectal adenoma

Meat type (quintiles)All adenoma (n = 3,696)TypeSite *Number
OR (95% CI) Nonadvanced (n = 2,271)Advanced (n = 1,425)Colon (n = 2,474)Rectum (n = 688)Single (n = 2,796)Multiple (n = 900)
OR (95% CI) OR (95% CI) OR (95% CI)
Total meat (g/d)
    Q2 (63.9-92.4)0.91 (0.81-1.03)0.89 (0.76-1.03)0.94 (0.79-1.13)0.94 (0.81-1.08)0.95 (0.73-1.24)0.93 (0.81-1.06)0.85 (0.67-1.07)
    Q3 (92.4-126.2)0.96 (0.85-1.08)1.00 (0.86-1.15)0.89 (0.74-1.07)0.95 (0.83-1.10)1.11 (0.86-1.44)1.00 (0.88-1.14)0.82 (0.65-1.04)
    Q4 (126.2-182.7)1.07 (0.94-1.20)1.04 (0.89-1.21)1.10 (0.91-1.33)1.06 (0.91-1.22)1.27 (0.97-1.66)1.10 (0.96-1.26)0.97 (0.76-1.23)
    Q5 (182.7-1212.7)1.05 (0.92-1.22)1.11 (0.93-1.33)0.97 (0.78-1.21)1.09 (0.92-1.30)1.14 (0.83-1.57)1.12 (0.95-1.32)0.88 (0.66-1.15)
    PtrendP = 0.09P = 0.05P = 0.78P = 0.08P = 0.28P = 0.04P = 0.79
Red meat (g/d)
    Q2 (29.2-48.7)0.95 (0.85-1.08)0.98 (0.85-1.15)0.90 (0.75-1.09)0.96 (0.83-1.10)0.98 (0.74-1.28)1.00 (0.87-1.14)0.82 (0.64-1.04)
    Q3 (48.7-72.8)0.97 (0.86-1.10)1.02 (0.88-1.19)0.89 (0.74-1.08)0.94 (0.81-1.08)1.15 (0.88-1.50)1.04 (0.90-1.19)0.78 (0.62-1.00)
    Q4 (72.8-113.8)1.07 (0.94-1.21)1.11 (0.95-1.30)1.00 (0.83-1.22)1.06 (0.91-1.24)1.30 (0.98-1.71)1.17 (1.01-1.35)0.81 (0.63-1.03)
    Q5 (113.8-845.4)1.07 (0.92-1.24)1.10 (0.91-1.31)1.03 (0.82-1.29)1.09 (0.92-1.30)1.14 (0.82-1.59)1.12 (0.95-1.32)0.91 (0.69-1.20)
    PtrendP = 0.13P = 0.23P = 0.29P = 0.09P = 0.38P = 0.10P = 0.81
White meat (g/d)
    Q2 (20.3-33.2)1.04 (0.93-1.16)1.03 (0.90-1.19)1.05 (0.88-1.24)1.03 (0.90-1.18)1.18 (0.93-1.51)1.09 (0.96-1.24)0.91 (0.74-1.12)
    Q3 (33.2-48.8)1.00 (0.90-1.12)0.95 (0.82-1.10)1.09 (0.92-1.30)1.03 (0.90-1.18)0.99 (0.77-1.28)1.07 (0.94-1.21)0.84 (0.68-1.04)
    Q4 (48.8-75.6)0.97 (0.86-1.09)0.99 (0.86-1.14)0.92 (0.77-1.12)0.99 (0.86-1.13)1.00 (0.77-1.29)0.99 (0.87-1.13)0.91 (0.74-1.13)
    Q5 (75.6-822.9)1.03 (0.91-1.16)1.02 (0.88-1.19)1.03 (0.85-1.24)1.02 (0.88-1.18)1.16 (0.89-1.52)1.09 (0.95-1.26)0.84 (0.67-1.06)
    PtrendP = 0.94P = 0.81P = 0.84P = 0.97P = 0.53P = 0.51P = 0.31
Red meat with known doneness level (g/d)
    Q2 (8.7-16.9)1.03 (0.91-1.17)0.93 (0.80-1.09)1.20 (0.98-1.46)1.12 (0.96-1.30)0.84 (0.64-1.10)0.98 (0.85-1.12)1.22 (0.95-1.57)
    Q3 (16.9-28.4)1.10 (0.97-1.25)1.07 (0.91-1.25)1.16 (0.94-1.43)1.13 (0.97-1.33)0.91 (0.68-1.20)1.08 (0.94-1.25)1.16 (0.88-1.51)
    Q4 (28.4-48.2)1.14 (1.00-1.31)1.10 (0.93-1.30)1.22 (0.99-1.52)1.15 (0.97-1.35)1.09 (0.81-1.45)1.17 (1.01-1.37)1.05 (0.80-1.39)
    Q5 (48.2-510.7)1.17 (1.00-1.35)1.08 (0.90-1.31)1.32 (1.04-1.67)1.26 (1.05-1.50)0.91 (0.66-1.27)1.15 (0.97-1.36)1.21 (0.90-1.62)
    PtrendP = 0.06P = 0.24P = 0.09P = 0.04P = 0.91P = 0.06P = 0.54
Red meat cooked rare/medium (g/d)
    Q2 (0.7-4.5)1.02 (0.90-1.15)1.01 (0.86-1.17)1.04 (0.86-1.27)1.02 (0.88-1.19)0.98 (0.75-1.28)1.09 (0.95-1.25)0.79 (0.61-1.02)
    Q3 (4.5-12.5)1.06 (0.94-1.20)1.06 (0.91-1.23)1.06 (0.87-1.28)1.06 (0.92-1.23)0.94 (0.72-1.24)1.03 (0.90-1.18)1.15 (0.91-1.45)
    Q4 (12.5-27.8)1.08 (0.96-1.22)1.07 (0.92-1.24)1.11 (0.91-1.34)1.08 (0.93-1.25)1.12 (0.86-1.46)1.14 (0.99-1.30)0.93 (0.73-1.18)
    Q5 (27.8-393.7)1.12 (0.99-1.28)1.10 (0.94-1.29)1.17 (0.96-1.43)1.13 (0.97-1.32)1.06 (0.80-1.41)1.13 (0.98-1.31)1.09 (0.86-1.39)
    PtrendP = 0.06P = 0.23P = 0.10P = 0.10P = 0.46P = 0.11P = 0.28
Red meat cooked well-done (g/d)
    Q2 (2.8-5.9)1.09 (0.97-1.23)1.10 (0.95-1.28)1.07 (0.89-1.29)1.11 (0.96-1.28)0.89 (0.69-1.15)1.12 (0.98-1.28)1.00 (0.79-1.26)
    Q3 (5.9-10.7)1.09 (0.97-1.23)1.07 (0.92-1.24)1.14 (0.95-1.37)1.14 (0.99-1.32)0.93 (0.72-1.20)1.18 (1.04-1.35)0.84 (0.66-1.07)
    Q4 (10.7-20.1)1.13 (1.00-1.28)1.20 (1.03-1.39)1.03 (0.85-1.25)1.10 (0.95-1.28)1.06 (0.82-1.37)1.17 (1.02-1.34)1.02 (0.80-1.28)
    Q5 (20.1-510.7)1.21 (1.06-1.37)1.25 (1.07-1.47)1.14 (0.93-1.40)1.23 (1.05-1.44)0.95 (0.71-1.26)1.27 (1.10-1.47)1.02 (0.79-1.31)
    PtrendP = 0.01P = 0.01P = 0.43P = 0.04P = 0.87P = 0.01P = 0.49
Processed meat (g/d)
    Q2 (3.8-7.9)1.01 (0.90-1.15)1.00 (0.86-1.17)1.03 (0.85-1.25)1.02 (0.88-1.18)0.92 (0.71-1.20)1.11 (0.96-1.27)0.74 (0.58-0.96)
    Q3 (7.9-14.3)0.95 (0.84-1.08)0.97 (0.83-1.14)0.92 (0.75-1.13)0.95 (0.81-1.10)0.92 (0.70-1.20)1.00 (0.87-1.16)0.80 (0.62-1.03)
    Q4 (14.3-26.8)1.12 (0.98-1.27)1.14 (0.97-1.34)1.08 (0.88-1.32)1.13 (0.96-1.32)0.96 (0.72-1.27)1.23 (1.06-1.42)0.82 (0.63-1.05)
    Q5 (26.8-367.1)1.04 (0.90-1.19)1.03 (0.86-1.23)1.06 (0.85-1.32)1.05 (0.89-1.25)0.86 (0.63-1.17)1.08 (0.92-1.27)0.90 (0.69-1.17)
    PtrendP = 0.51P = 0.71P = 0.48P = 0.46P = 0.46P = 0.66P = 0.51
Bacon/sausage (g/d)
    Q2 (0.5-1.3)1.08 (0.95-1.22)1.01 (0.86-1.17)1.21 (1.00-1.46)1.16 (1.00-1.34)0.76 (0.58-0.98)1.07 (0.93-1.22)1.12 (0.88-1.43)
    Q3 (1.3-2.9)1.02 (0.90-1.15)0.99 (0.85-1.16)1.06 (0.87-1.29)1.08 (0.93-1.26)0.83 (0.64-1.07)1.05 (0.91-1.21)0.92 (0.72-1.18)
    Q4 (2.9-6.3)1.01 (0.89-1.14)0.96 (0.82-1.13)1.10 (0.90-1.34)1.09 (0.94-1.28)0.72 (0.55-0.94)1.07 (0.92-1.23)0.84 (0.65-1.08)
    Q5 (6.3-306.0)1.14 (1.00-1.30)1.15 (0.98-1.36)1.13 (0.92-1.40)1.20 (1.02-1.41)0.86 (0.65-1.14)1.15 (0.99-1.34)1.11 (0.86-1.43)
    PtrendP = 0.03P = 0.01P = 0.56P = 0.09P = 0.75P = 0.05P = 0.22
  • * Five hundred thirty-four adenoma cases could not be strictly classified as one of these two subsites.

  • Models were adjusted for age, gender, screening center, energy intake (kcal/d, standard method for energy adjustment), ethnicity (American Indian/Alaskan Native, Asian, Hispanic, non-Hispanic Black, non-Hispanic White, or Pacific Islander), educational attainment (<8 years school, 8-11 years school, 12 years school/high school equivalent, post–high school other than college, some college, college graduate, or postgraduate), tobacco use (never, smoked cigar or pipe, quit smoking 20+ years and smoked ≤1 pack/d, quit 20+ years and smoked >1 pack/d, quit <20 years and smoked ≤1 pack/d, quit <20 years and smoked >1 pack/d, or unknown), alcohol use (<1, ≥1-15, >15-30, or >30 g/d), use of aspirin and ibuprofen separately (no regular use, <2, 2-3, 4, 8, 12-16, 30, or 60 per month), vigorous physical activity (none, <1, 1, 2, 3, or 4+ hours/wk), BMI (calculated as kg/m2), total folate intake (μg/d), calcium intake (mg/d), and dietary fiber intake (g/d).