DNA adducts and lung cancer: crude estimates and conditional logistic regression models
| Cases/controls | Crude OR (95% CI) | Conditional OR (95% CI) | |
|---|---|---|---|
| Detectable adducts | 102/893 | ||
| Nondetectable adducts | 13/193 | ||
| All subjects | 1.69 (0.93-3.08) | 1.86 (0.88-3.93) | |
| Adjusted by center | 2.05 (0.83-5.04) | ||
| Never-smokers | 1.67 (0.69-4.01) | 4.04 (1.06-15.42) | |
| Ex-smokers | 1.69 (0.74-3.84) | 2.26 (0.78-6.53) | |
| Age groups (y) | |||
| <55 | 6.90 (0.91-52.1) | 5.56 (0.75-41.23) | |
| 55-65 | 1.07 (0.62-1.84) | 2.62 (0.53-13.00) | |
| >65 | 1.51 (0.67-3.44) | 0.81 (0.14-4.47) | |
| Above versus below median in controls (0.6 DNA adducts per 108 normal nucleotides), excluding nondetectable levels | |||
| All subjects | |||
| Below median | 42/322 | 1.00 (—) | 1.00 (—) |
| Above median | 60/571 | 0.98 (0.67-1.44) | 0.83 (0.49-1.41) |
| Never-smokers | |||
| Below median | 11/167 | 1.00 (—) | 1.00 (—) |
| Above median | 34/318 | 1.73 (0.94-3.16) | 2.35 (0.98-5.65) |
| Ex-smokers | |||
| Below median | 31/155 | 1.00 (—) | 1.00 (—) |
| Above median | 26/253 | 0.64 (0.38-1.10) | 0.36 (0.16-0.78) |
| Nondetectable adducts, below and above median (median adduct value in controls, 0.6 DNA adducts per 108 normal nucleotides) | |||
| All subjects | |||
| Undetectable * | 1.00 (—) | 1.00 (—) | |
| Below median | 1.95 (1.01-3.70) | 2.51 (0.96-6.55) | |
| Above median | 1.56 (0.84-2.90) | 1.54 (0.58-4.07) | |
| DNA adducts as continuous variable | 1.25 (0.69-2.27) | ||
| P for trend | 0.84 † | ||
| Never-smokers | |||
| Undetectable | 1.00 (—) | 1.00 (—) | |
| Below median | 1.18 (0.42-3.30) | 4.47 (0.73-27.24) | |
| Above median | 1.92 (0.78-4.71) | 6.81 (1.11-41.64) | |
| DNA adducts as continuous variable | 2.17 (0.96-4.89) | ||
| P for trend | 0.04 † | ||
| Ex-smokers | |||
| Undetectable | 1.00 (—) | 1.00 (—) | |
| Below median | 2.43 (1.02-5.74) | 4.93 (1.06-22.98) | |
| Above median | 1.25 (0.52-2.97) | 0.80 (0.18-3.65) | |
| DNA adducts as continuous variable | 0.59 (0.27-1.33) | ||
| P for trend | 0.17 † | ||
NOTE: In addition to matching variables, estimates are adjusted for education (years of school), BMI, physical activity, and intake of fruits, vegetables, meat, and energy.
↵* Reference category. Conditional ORs adjusted as above and by center.
↵† Log transformation of DNA adducts as continuous variable.