Table 1.

Surviving fraction after 2 Gy (SF2) in cell lines ± HPIs

Cell lineCancer typeMutationControl SF2, n (mean ± SD)Amprenavir SF2, n (mean ± SD) [P]Nelfinavir SF2, n (mean ± SD) [P]
T24BladderH-Ras6 (0.560 ± 0.061)6 (0.370 ± 0.022) [<0.001 *]6 (0.452 ± 0.023) [0.006 *]
SQ20BHead and neckEGFR6 (0.691 ± 0.042)6 (0.432 ± 0.017) [<0.001 *]5 (0.401 ± 0.024) [<0.001 *]
MIAPACA2PancreaticK-Ras4 (0.906 ± 0.086)5 (0.664 ± 0.051) [0.001 *]5 (0.526 ± 0.040) [0.001 *]
A549LungK-Ras6 (0.570 ± 0.042)5 (0.487 ± 0.030) [0.002 *]4 (0.401 ± 0.062) [<0.001 *]
REFRat fibroblastsNone5 (0.408 ± 0.040)4 (0.402 ± 0.136) [0.89 *]5 (0.397 ± 0.054) [0.89 *]
  • * Compared with control SF2 by t test.