Table 2.

Test of synergy in SQ20B xenografts for in vivo to in vitro clonogenicity with radiation and amprenavir or radiation and nelfinavir

Log10 plating efficiency mean * ± SD (no. measures per mouse)
Control (n = 4)8 Gy (n = 5)Amprenavir (n = 5)8 Gy + Amprenavir (n = 4)Nelfinavir (n = 3)8 Gy + Nelfinavir (n = 4)
−1.24 ± 0.06 (8-12)−1.54 ± 0.09 (8-12)−1.21 ± 0.13 (8-12)−2.37 ± 0.25 (6-12)−1.29 ± 0.05 (4-6)−2.30 ± 0.24 (6-7)
Interaction term β (SE)−0.864 (0.138)−0.707 (0.137)
Wald statistic−6.283−5.153
Test of synergy (one-sided P)<0.001<0.001
  • * Mean of the averages for each mouse.